SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-531607"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-531607" > Associations Betwee...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004569naa a2200505 4500
001oai:DiVA.org:uu-531607
003SwePub
008240618s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5316072 URI
0247 a https://doi.org/10.29399/npa.281272 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tetik, Melikeu Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.4 aut
2451 0a Associations Between Blood Levels of NLRP3 Inflammasome Components and Obsessive Compulsive Disorder
264 1b Turk Noropsikiyatri Dernegi,c 2023
338 a print2 rdacarrier
520 a Introduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regarding the underlying mechanisms are yet to be revealed. The NLRP3 inflammasome complex is an important component of the innate immune system that initiates and mediates inflammatory response to a variety of stimuli. This study aims to inquire into a possible association between NLRP3 inflammasome complex and OCD. Methods: This case-control study included 103 participants (51 cases with OCD and 52 healthy controls). All participants were evaluated with the Yale Brown Obsessive Compulsive Scale, Hamilton Depression Scale, and Hewitt Multidimensional Perfectionism Scale. RNA and proteins were extracted from peripheral blood mononuclear cells. Expression of NLRP3 inflammasome components were determined using quantitative real-time polymerase chain reaction (PCR) and Western blotting. Levels of Serum IL-1beta and IL-18 cytokine were determined by ELISA. Results: NEK7 and CASP1 mRNA levels were significantly higher in OCD patients, compared to controls. Pro-caspase-1 protein levels were elevated, as well. Regression analysis showed that NEK7 mRNA and procaspase-1 protein levels can differentiate OCD and healthy control groups. Conclusion: Our results provide insight into the molecular alterations that could explain the inflammation-OCD association.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a ASC
653 a caspase-1
653 a inflammasome
653 a NEK7
653 a NLRP3
653 a obsessive-compulsive disorder
7001 a Direk, Neseu Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.4 aut
7001 a Uzgan, Betul Onderu Canakkale Onsekiz Mart Univ, Dept Biol, Canakkale, Turkiye.4 aut
7001 a Aykac, Cansuu Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.4 aut
7001 a Ekinci, Burcuu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut
7001 a Yaras, Tutkuu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut
7001 a Kuruoglu, Aykutu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.4 aut
7001 a Özel, Fatihu Uppsala universitet,Fysiologi och miljötoxikologi4 aut0 (Swepub:uu)fatoz136
7001 a Ermis, Cagatayu Dokuz Eylul Univ, Fac Med, Dept Child & Adolescent Psychiat, Izmir, Turkiye.4 aut
7001 a Alkin, Tuncu Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.4 aut
7001 a Oktay, Yavuzu Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Med Biol, Izmir, Turkiye.4 aut
7102 a Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.b Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.4 org
7730 t Nöropsikiyatri Arşivid : Turk Noropsikiyatri Dernegig 60:1, s. 28-36q 60:1<28-36x 1300-0667
7730 t Archives of Neuropsychiatryd : Turk Noropsikiyatri Dernegig 60:1, s. 28-36q 60:1<28-36x 1309-4866
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531607
8564 8u https://doi.org/10.29399/npa.28127

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy