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Affibody PET Imagin...
Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy
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- Eissler, Nina (författare)
- Affibody AB, S-17165 Solna, Sweden.
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- Altena, Renske (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, S-17164 Solna, Sweden.;Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Med Unit Breast Endocrine Tumors & Sarcoma, Theme Canc, S-17164 Solna, Sweden.;Karolinska Univ Hosp, Funct Unit Nucl Med, Med Radiat Phys & Nucl Med, S-14157 Huddinge, Sweden.
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- Alhuseinalkhudhur, Ali (författare)
- Uppsala universitet,Cancerimmunterapi,Molekylär avbildning och medicinsk fysik
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- Bragina, Olga (författare)
- Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Dept Nucl Therapy & Diagnost, Tomsk 634055, Russia.;Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Res Ctr Oncotheranost, Tomsk 634050, Russia.
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- Feldwisch, Joachim (författare)
- Affibody AB, S-17165 Solna, Sweden.
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- Wuerth, Guido (författare)
- Affibody AB, S-17165 Solna, Sweden.
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- Loftenius, Annika (författare)
- Affibody AB, S-17165 Solna, Sweden.
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- Brun, Nikolai (författare)
- Affibody AB, S-17165 Solna, Sweden.
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- Axelsson, Rimma (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Funct Unit Nucl Med, Med Radiat Phys & Nucl Med, S-14157 Huddinge, Sweden.;Karolinska Inst, Dept Mol Med & Surg, S-14152 Stockholm, Sweden.
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- Tolmachev, Vladimir (författare)
- Uppsala universitet,Cancerprecisionsmedicin
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- Sörensen, Jens (författare)
- Uppsala universitet,Molekylär avbildning och medicinsk fysik
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- Frejd, Fredrik (författare)
- Uppsala universitet,Cancerprecisionsmedicin,Affibody AB, S-17165 Solna, Sweden.
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Karolinska Institutet Affibody AB, S-17165 Solna, Sweden (creator_code:org_t)
- MDPI, 2024
- 2024
- Engelska.
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Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 12:5
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Human epidermal growth factor receptor 2 (HER2) is a major prognostic and predictive marker overexpressed in 15-20% of breast cancers. The diagnostic reference standard for selecting patients for HER2-targeted therapy is based on the analysis of tumor biopsies. Previously patients were defined as HER2-positive or -negative; however, with the approval of novel treatment options, specifically the antibody-drug conjugate trastuzumab deruxtecan, many breast cancer patients with tumors expressing low levels of HER2 have become eligible for HER2-targeted therapy. Such patients will need to be reliably identified by suitable diagnostic methods. Biopsy-based diagnostics are invasive, and repeat biopsies are not always feasible. They cannot visualize the heterogeneity of HER2 expression, leading to a substantial number of misdiagnosed patients. An alternative and highly accurate diagnostic method is molecular imaging with radiotracers. In the case of HER2, various studies demonstrate the clinical utility and feasibility of such approaches. Radiotracers based on Affibody((R)) molecules, small, engineered affinity proteins with a size of similar to 6.5 kDa, are clinically validated molecules with favorable characteristics for imaging. In this article, we summarize the HER2-targeted therapeutic landscape, describe our experience with imaging diagnostics for HER2, and review the currently available clinical data on HER2-Affibody-based molecular imaging as a novel diagnostic tool in breast cancer and beyond.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- HER2
- breast cancer
- diagnostics
- molecular imaging
- Affibody molecules
- clinical trials
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Eissler, Nina
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Altena, Renske
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Alhuseinalkhudhu ...
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Bragina, Olga
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Feldwisch, Joach ...
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Wuerth, Guido
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visa fler...
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Loftenius, Annik ...
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Brun, Nikolai
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Axelsson, Rimma
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Tolmachev, Vladi ...
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Sörensen, Jens
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Frejd, Fredrik
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Artiklar i publikationen
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Biomedicines
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet