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Dupilumab for relap...
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis : a European retrospective study
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- Molina, Berengere (författare)
- Hosp Cochin, Dept Internal Med, Paris, France.
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- Padoan, Roberto (författare)
- Univ Padua, Dept Med DIMED, Div Rheumatol, Padua, Italy.
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- Urban, Maria Letizia (författare)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy.
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- Novikov, Pavel (författare)
- IM Sechenov First Moscow State Med Univ, Tareev Clin Internal Dis, Moscow, Russia.
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- Caminati, Marco (författare)
- Univ Verona, Dept Med Asthma Allergy & Clin Immunol, Verona, Italy.
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- Taillé, Camille (författare)
- Nord Univ Paris Cite, Bichat Hosp, Dept Resp Dis, APHP, Paris, France.
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- Néel, Antoine (författare)
- Nantes Univ Hosp, Dept Internal Med, Nantes, France.
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- Bouillet, Laurence (författare)
- Grenoble Alpes Univ Hosp, T Reg Unit, CNRS, UMR 5525,5,VetAgro Sup, Grenoble, France.;Grenoble Univ Hosp, Internal Med Dept, Grenoble, France.
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- Fraticelli, Paolo (författare)
- Univ Hosp Osped Riuniti, Internal Med Dept, Ancona, Italy.
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- Schleinitz, Nicolas (författare)
- Aix Marseille Univ, Timone Hosp AP HM, Dept Internal Med, Marseille, France.
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- Christides, Christine (författare)
- Avignon Hosp, Dept Internal Med, Avignon, France.
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- Moi, Laura (författare)
- Valais Hosp, Inst Cent Hop, Immunol & Allergol, Sion, Switzerland.
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- Godeau, Bertrand (författare)
- Henri Mondor Univ Hosp, Dept Internal Med, Creteil, France.
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- Knight, Ann (författare)
- Uppsala universitet,Reumatologi
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- Schroeder, Jan Walter (författare)
- ASST Grande Osped Metropolitano Niguarda, Unit Allergol & Immunol, Milan, Italy.
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- Marchand-Adam, Sylvain (författare)
- Reg Univ Hosp Ctr, Dept Resp Med, Tours, France.
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- Gil, Helder (författare)
- Besancon Univ Hosp, Dept Internal Med, Besancon, France.
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- Cottin, Vincent (författare)
- Louis Pradel Hosp, Coordinating Reference Ctr Rare Pulm Dis, Dept Resp Med, Bron, France.
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- Durel, Cécile-Audrey (författare)
- Univ Hosp Edouard Herriot, Dept Internal Med, HCL, Lyon, France.
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- Gelain, Elena (författare)
- Meyer Childrens Hosp, Nephrol & Dialysis Unit, Florence, Italy.
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- Lerais, Boris (författare)
- Brest Univ Hosp, Dept Internal Med, Brest, France.
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- Ruivard, Marc (författare)
- Univ Hosp Ctr, Internal Med, Clermont Ferrand, France.
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- Groh, Matthieu (författare)
- Foch Hosp, Natl Referral Ctr Hypereosinophil Syndrome CEREO, Dept Internal Med, Suresnes, France.
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- Samson, Maxime (författare)
- Univ Hosp Ctr, Dept Internal Med & Clin Immunol, Dijon, France.;Univ Bourgogne Franche Comte, INSERM, EFS BFC, UMR1098,RIGHT Interact Greffon Hote Tumeur Ingenie, Dijon, France.
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- Moroni, Luca (författare)
- Ist Sci San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis UnIRAR, Milan, Italy.
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- Thiel, Jens (författare)
- Univ Freiburg, Med Ctr, Dept Rheumatol & Clin Immunol, Freiburg, Germany.;Med Univ, Dept Internal Med, Div Rheumatol & Clin Immunol, Graz, Austria.
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- Kernder, Anna (författare)
- Heinrich Heine Univ Dusseldorf, Med Fac, Dept Rheumatol & Hiller Res Unit Rheumatol, Dusseldorf, Germany.
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- Cohen Tervaert, Jan Willem (författare)
- Univ Alberta, Dept Med, Edmonton, AB, Canada.;Maastricht Univ, Sch Mental Hlth & Neurosci, Maastricht, Netherlands.
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- Costanzo, Giulia (författare)
- Univ Cagliari, Dept Med Sci & Publ Hlth, Monserrato, Italy.
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- Folci, Marco (författare)
- Fdn Poliambulanza Ist Osped, Brescia, Italy.
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- Rizzello, Sonia (författare)
- Careggi Univ Hosp, Severe Asthma Unit, Florence, Italy.
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- Cohen, Pascal (författare)
- Cochin Hosp, Dept Internal Med, Paris, France.
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- Emmi, Giacomo (författare)
- Univ Florence, Dept Expt & Clin Med, Florence, Italy.;Monash Univ, Ctr Inflammatory Dis, Monash Med Ctr, Dept Med, Clayton, Vic, Australia.
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- Terrier, Benjamin (författare)
- Hosp Cochin, Dept Internal Med, F-75014 Paris, Ile De France, France.;Hosp Cochin, Dept Internal Med, Paris, France.
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Hosp Cochin, Dept Internal Med, Paris, France Univ Padua, Dept Med DIMED, Div Rheumatol, Padua, Italy. (creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 82:12, s. 1587-1593
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated with glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations. When immunosuppressants and/or mepolizumab are ineffective, dupilumab could be an option. We describe the safety and efficacy of off-label use of dupilumab in relapsing and/or refractory EGPA.Patients and methods We conducted an observational multicentre study of EGPA patients treated with dupilumab. Complete response was defined by Birmingham Vasculitis Activity Score (BVAS)=0 and prednisone dose ≤4 mg/day, and partial response by BVAS=0 and prednisone dose >4 mg/day. Eosinophilia was defined as an eosinophil count >500/mm3.Results Fifty-one patients were included. The primary indication for dupilumab was disabling ENT symptoms in 92%. After a median follow-up of 13.1 months, 18 patients (35%) reported adverse events (AEs), including two serious AEs. Eosinophilia was reported in 34 patients (67%), with a peak of 2195/mm3 (IQR 1268–4501) occurring at 13 weeks (IQR 4–36) and was associated with relapse in 41%. Twenty-one patients (41%) achieved a complete response and 12 (24%) a partial response. Sixteen (31%) patients experienced an EGPA relapse while on dupilumab, which was associated with blood eosinophilia in 14/16 (88%) patients. The median eosinophil count at the start of dupilumab was significantly lower in relapsers than in non-relapsers, as was the median time between stopping anti-IL-5/IL-5R and switching to dupilumab.Conclusion These results suggest that dupilumab may be effective in treating patients with EGPA-related ENT manifestations. However, EGPA flares occurred in one-third of patients and were preceded by eosinophilia in 88%, suggesting that caution is required.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Systemic vasculitis
- Immune System Diseases
- Biological Therapy
- Autoimmune Diseases
- Therapeutics
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- ref (ämneskategori)
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- Av författaren/redakt...
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Molina, Berenger ...
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Padoan, Roberto
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Urban, Maria Let ...
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Novikov, Pavel
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Caminati, Marco
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Taillé, Camille
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visa fler...
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Néel, Antoine
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Bouillet, Lauren ...
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Fraticelli, Paol ...
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Schleinitz, Nico ...
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Christides, Chri ...
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Moi, Laura
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Godeau, Bertrand
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Knight, Ann
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Schroeder, Jan W ...
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Marchand-Adam, S ...
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Gil, Helder
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Cottin, Vincent
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Durel, Cécile-Au ...
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Gelain, Elena
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Lerais, Boris
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Ruivard, Marc
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Groh, Matthieu
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Samson, Maxime
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Moroni, Luca
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Thiel, Jens
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Kernder, Anna
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Cohen Tervaert, ...
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Costanzo, Giulia
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Folci, Marco
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Rizzello, Sonia
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Cohen, Pascal
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Emmi, Giacomo
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Terrier, Benjami ...
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och Reumatologi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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