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The predictive valu...
The predictive value of cardiovascular outcomes and mortality assessed by the C-reactive protein to albumin ratio in the UK Biobank
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- Wändell, Per (författare)
- Karolinska Institute,Karolinska Institutet
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- Carlsson, Axel C (författare)
- Karolinska Institute,Karolinska Institutet
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- Larsson, Anders O (författare)
- Uppsala universitet,Klinisk kemi,Uppsala University, Uppsala
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institute,Dalarna University College,Högskolan Dalarna,Uppsala universitet,Centrum för klinisk forskning Dalarna,Division of Family Medicine and Primary Care, NVS Department, Karolinska Institutet,,Medicinsk vetenskap,Karolinska Institutet, Huddinge
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- Ruge, Toralph (författare)
- Karolinska Institute,Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Rydell, Andreas (författare)
- Karolinska Institute
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(creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: BMC Cardiovascular Disorders. - : BioMed Central (BMC). - 1471-2261. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The C-reactive protein/albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, yet less is known about if CAR is superior to C-reactive protein (CRP) in the general population.METHODS: Prospective study design on the UK Biobank, where serum samples of CRP and Albumin were used. Cox regression analyses were conducted to assess all-cause and cardiovascular mortality, myocardial infarction, ischemic stroke, and heart failure over a follow-up period of approximately 12.5 years. The Cox model was adjusted for established cardiovascular disease (CVD) risk factors, including age, sex, smoking habits, physical activity level, BMI level, systolic blood pressure, LDL-cholesterol, statin treatment, diabetes, and previous CVD, with hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Analyses were also stratified by sex, CRP level (< 10 and ≥ 10 mg/ml) and age (< 60 and ≥ 60 years).RESULTS: In total, 411,506 individuals (186,043 men and 225,463 women) were included. In comparisons between HRs for all adverse outcomes, the results were similar or identical for CAR and CRP. For example, both CAR and CRP, adjusted HRs for all-cause mortality were 1.13 (95% CI 1.12-1.14). Regarding CVD mortality, the adjusted HR for CAR was 1.14 (95% CI 1.12-1.15), while for CRP, it was 1.13 (95% CI 1.11-1.15).CONCLUSIONS: Within this study CAR was not superior to CRP in predictive ability of mortality or CVD disorders.CLINICAL TRIAL REGISTRATION NUMBER: Not applicable (cohort study).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Albumin
- Blood pressure
- CRP
- Cardiovascular mortality
- Diabetes
- Albumin
- Blood pressure
- Cardiovascular mortality
- CRP
- Diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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