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Hormonal, liver, an...
Hormonal, liver, and renal function associated with electronic waste (e-waste) exposure in Dhaka, Bangladesh
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- Parvez, Sarker Masud (författare)
- Univ Queensland, Child Hlth Res Ctr, Childrens Hlth & Environm Program, South Brisbane, Qld 4101, Australia.;icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh.
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- Huda, M. Mamun (författare)
- Charles Sturt Univ, Rural Hlth Res Inst, Orange, NSW 2800, Australia.
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- Rahman, Mahbubur (författare)
- Uppsala universitet,Internationell barnhälsa och nutrition,icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh.
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- Jahan, Farjana (författare)
- icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh.
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- Fujimura, Masatake (författare)
- Natl Inst Minamata Dis, Dept Basic Med Sci, Minamata, Kumamoto 8670008, Japan.
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- Hasan, Shaikh Sharif (författare)
- icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh.
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- Hares, Abul (författare)
- icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh.
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- Islam, Zahir (författare)
- Univ Queensland, Child Hlth Res Ctr, Childrens Hlth & Environm Program, South Brisbane, Qld 4101, Australia.
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- Raqib, Rubhana (författare)
- icddr b, Nutr Res Div, Dhaka 1212, Bangladesh.
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- Knibbs, Luke D. (författare)
- Univ Sydney, Fac Med & Hlth, Sch Publ Hlth, Sydney, NSW 2050, Australia.;Sydney Local Hlth Dist, Publ Hlth Unit, Publ Hlth Res Analyt & Methods Evidence, Camperdown, NSW 2050, Australia.
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- Sly, Peter D. (författare)
- Univ Queensland, Child Hlth Res Ctr, Childrens Hlth & Environm Program, South Brisbane, Qld 4101, Australia.
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Univ Queensland, Child Hlth Res Ctr, Childrens Hlth & Environm Program, South Brisbane, Qld 4101, Australia;icddr b, Hlth Syst & Populat Studies Div, Environm Hlth & WASH, Dhaka 1212, Bangladesh. Charles Sturt Univ, Rural Hlth Res Inst, Orange, NSW 2800, Australia. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Toxicology. - : Elsevier. - 0300-483X .- 1879-3185. ; 505
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Electronic waste (e-waste) contains numerous metals and organic pollutants that have detrimental impacts on human health. We studied 199 e-waste recycling workers and 104 non-exposed workers; analyzed blood, urine, and hair samples to measure heavy metals, hormonal, liver, and renal function. We used quantile regression models to evaluate the impact of Pb, Cd, and Hg on hormonal, liver and renal function, and the role of DNA oxidative damage in mediating the relationship between exposures and outcomes. Exposed workers had higher blood lead (Pb) (median 11.89 vs 3.63 mu g/dL), similar blood cadmium (Cd) (1.04 vs 0.99 mu g/L) and lower total mercury (Hg) in hair (0.38 vs 0.57 ppm) than non-exposed group. Exposed workers also had elevated median concentrations of total triiodothyronine (TT3), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urinary albumin, albumin creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were significantly higher than non-exposed group (p <= 0.05). Sex hormones including luteinizing hormone, follicle stimulating hormone, estrogen, progesterone and testosterone concentrations were not significantly different between exposed and non-exposed (all p >= 0.05). The median concentration of ALT was 4.00 (95% CI: 0.23, 7.77), urinary albumin was 0.09 (95% CI: 0.06, 0.12) and ACR was 1.31 (95% CI: 0.57, 2.05) units higher in the exposed group compared to non-exposed group. Pb was associated with a 3.67 unit increase in the ALP (95% CI: 1.53, 5.80), 0.01 unit increase in urinary albumin (95% CI: 0.002, 0.01), and 0.07 unit increase in ACR (95% CI: 0.01, 0.13). However, no hormonal, renal, and hepatic parameters were associated with Cd or Hg. Oxidative DNA damage did not mediate exposure-outcome relationships (p >= 0.05). Our data indicate e-waste exposure impairs liver and renal functions secondary to elevated Pb levels. Continuous monitoring, longitudinal studies to evaluate the dose-response relationship and effective control measure are required to protect workers from ewaste exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- E -waste
- Heavy metals
- Hormone
- Liver
- Renal
- Bangladesh
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Parvez, Sarker M ...
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Huda, M. Mamun
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Rahman, Mahbubur
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Jahan, Farjana
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Fujimura, Masata ...
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Hasan, Shaikh Sh ...
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visa fler...
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Hares, Abul
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Islam, Zahir
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Raqib, Rubhana
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Knibbs, Luke D.
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Sly, Peter D.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Toxicology
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Uppsala universitet