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Sökning: onr:"swepub:oai:DiVA.org:uu-535796" > Iodine and other fa...

  • Mathews, Divya M.Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand. (författare)

Iodine and other factors associated with fertility outcome following oil-soluble contrast medium hysterosalpingography : a prospective cohort study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Frontiers Media S.A.2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-535796
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535796URI
  • https://doi.org/10.3389/fendo.2024.1257888DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To examine factors associated with fertility following hysterosalpingography (HSG) using an oil-soluble contrast medium (OSCM).Design: In a prospective cohort study on 196 women undergoing OSCM HSG, we showed that iodine excess was almost universal (98%) and mild subclinical hypothyroidism was frequent (38%). Here, we report the analyses of secondary outcomes examining factors associated with the likelihood of pregnancy following the HSG.Setting: Auckland, New Zealand (2019-2021).Sample: 196 women with primary or secondary infertility who underwent OSCM HSG.Methods: Baseline and serial urine iodine concentrations (UIC) and thyroid function tests were measured over six months following the HSG. Pregnancy and treatment with levothyroxine during the study period were documented.Results: Following OSCM HSG, pregnancy rates were 49% in women aged <40 years (77/158) but considerably lower (16%) among those >= 40 years (6/38). Similarly, live birth rates were markedly lower in women >= 40 years (17%; 1/6) versus <40 years (73%; 56/77). 29% of participants were iodine deficient at baseline despite advice recommending iodine fortification. Following HSG, the likelihood of pregnancy in women with moderate iodine deficiency was 64% higher than in women with normal iodine levels (p=0.048). Among women aged <40 years who had subclinical hypothyroidism (n=75), levothyroxine treatment was associated with higher pregnancy rates compared to untreated women [63% (26/48) vs 37% (10/27), respectively; p=0.047].Conclusion: OSCM HSG was associated with higher pregnancy rates in women <= 40 than in those aged >40 years. Iodine deficiency was relatively common in this cohort, and increased iodine levels from OSCM exposure may contribute to the improved fertility observed with this procedure.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Peart, Jane M.Auckland Radiol Grp, Auckland, New Zealand. (författare)
  • Sim, Robert G.Auckland Radiol Grp, Auckland, New Zealand. (författare)
  • Johnson, Neil P.Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.;Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand.;Repromed Auckland, Auckland, New Zealand. (författare)
  • O'Sullivan, SusannahAuckland Dist Hlth Board, Endocrinol Greenlane Clin Ctr, Auckland, New Zealand. (författare)
  • Derraik, José G. B.Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Fac Med & Hlth Sci, Dept Paediatrics: Child & Youth Hlth, Auckland, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.(Swepub:uu)josde820 (författare)
  • Hofman, Paul L.Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand. (författare)
  • Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand.Auckland Radiol Grp, Auckland, New Zealand. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Endocrinology: Frontiers Media S.A.151664-2392

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