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Sökning: onr:"swepub:oai:DiVA.org:uu-535868" > Hemangiosarcoma Cel...

Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion

Kim, Jong Hyuk (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA.;Univ Florida, Hlth Canc Ctr, Gainesville, FL USA.;Univ Florida, Intelligent Crit Care Ctr, Gainesville, FL USA.;Univ Florida, Artificial Intelligence Acad Initiat AI2 Ctr, Gainesville, FL USA.
Schulte, Ashley J. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Sarver, Aaron L. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Inst Hlth Informat, Minneapolis, MN USA.
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Lee, Donghee (författare)
Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA.
Angelos, Mathew G. (författare)
Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN USA.;Univ Minnesota, Microbiol Immunol & Canc Biol MICaB Grad Program, Minneapolis, MN USA.;Univ Penn, Sch Med, Dept Med, Div Hematol & Oncol, Philadelphia, PA USA.
Frantz, Aric M. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Capstan Therapeut, San Diego, CA USA.
Forster, Colleen L. (författare)
Univ Minnesota, Biol Mat Procurement Network BioNet, Minneapolis, MN USA.
O'Brien, Timothy D. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.
Cornax, Ingrid (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.;Janssen Res & Dev LLC, Horsham, PA USA.
O'Sullivan, M. Gerard (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.
Cheng, Nuojin (författare)
Univ Minnesota, Coll Sci & Engn, Sch Math, Minneapolis, MN USA.;Univ Colorado, Appl Math, Boulder, CO USA.
Lewellen, Mitzi (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Oseth, LeAnn (författare)
Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Kumar, Sunil (författare)
Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.
Bullman, Susan (författare)
Broad Inst MIT & Harvard, Cambridge, MA USA.;Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA USA.
Pedamallu, Chandra Sekhar (författare)
Broad Inst MIT & Harvard, Cambridge, MA USA.;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.
Goyal, Sagar M. (författare)
Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.
Meyerson, Matthew (författare)
Broad Inst MIT & Harvard, Cambridge, MA USA.;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.
Lund, Troy C. (författare)
Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN USA.
Breen, Matthew (författare)
North Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA.;North Carolina State Univ, Comparat Med Inst, Raleigh, NC USA.;Univ N Carolina, Lineberger Comprehens Canc Ctr, Canc Genet Program, Raleigh, NC USA.
Lindblad-Toh, Kerstin (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA USA.
Dickerson, Erin B. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Kaufman, Dan S. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN USA.;Univ Minnesota, Ctr Immunol, Minneapolis, MN USA.;Univ Calif San Diego, Dept Med, Div Regenerat Med, La Jolla, CA USA.
Modiano, Jaime F. (författare)
Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Ctr Immunol, Minneapolis, MN USA.;Univ Minnesota, Dept Lab Med & Pathol, Med Sch, Minneapolis, MN USA.;Univ Minnesota, Ctr Engn Med, Minneapolis, MN USA.
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Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA.;Univ Florida, Hlth Canc Ctr, Gainesville, FL USA.;Univ Florida, Intelligent Crit Care Ctr, Gainesville, FL USA.;Univ Florida, Artificial Intelligence Acad Initiat AI2 Ctr, Gainesville, FL USA. Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (creator_code:org_t)
American Association For Cancer Research (AACR), 2024
2024
Engelska.
Ingår i: Cancer Research Communications. - : American Association For Cancer Research (AACR). - 2767-9764. ; 4:6, s. 1467-1480
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.Significance: We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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