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Divergent effects o...
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von zur Mühlen, BengtUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
Divergent effects of different beta-blocking agents onendothelium-dependent vasodilatation in the human forearm
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
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2009-07-08
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Informa UK Limited,2000
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-55046
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55046URI
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https://doi.org/10.1080/080370500448687DOI
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Språk:engelska
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Sammanfattning på:engelska
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OBJECTIVE: The aim of this study was to evaluate the direct effect of three principally different beta-receptor blocking agents on endothelium-dependent vasodilatation (EDV) in the human forearm. METHODS: In 27 young normotensive subjects forearm blood flow (FBF) was measured with venous occlusion plethysmography during local intra-arterial infusions of methacholine (MCh), evaluating EDV, and sodium nitroprusside (SNP), evaluating endothelium-independent vasodilatation (EIDV). The measurements of EDV and EIDV were undertaken at baseline conditions and repeated after 1 h of concomitant intra-arterial infusion of atenolol (n = 8, 1.2 mg/h), propranolol (n = 7, 1.2 mg/h), labetalol (n = 7, 16 mg/h) or saline (n = 5). RESULTS: The selective beta-blocker atenolol showed a tendency to improve the FBF response to MCh (from 28.8 +/- 9.2 to 32.6 +/- 8.7 ml/min/ml tissue, p < 0.05). The nonselective beta-blocker propranolol attenuated the FBF response to MCh significantly (from 30.5 +/- 6.7 to 22.8 +/- 4.5 ml/min/ml tissue, p < 0.01). In these groups baseline FBF and EIDV were unchanged. Labetalol, a combined non-selective beta-blocker and selective alpha-1-blocker, increased baseline FBF and increased the response to both MCh and SNP in parallel (p < 0.05 for MCh and p = 0.07 for SNP). Saline did not change baseline FBF, EDV or EIDV. CONCLUSIONS: This study showed that local infusion of different beta-blocking agents in normotensive subjects affects endothelial vasodilatory function differently. This technique could be used to evaluate the direct effect of vasoactive drugs on EDV.
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Millgård, JonasUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood Pressure: Informa UK Limited9:5, s. 287-2920803-70511651-1999
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