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Assessment of eryth...
Assessment of erythropoiesis following renal transplantation
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- Beshara, Soheir (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Birgegård, Gunnar (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Goch, J. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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visa fler...
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- Wahlberg, Jan (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Transplantation Surgery
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- Wikström, Björn (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Danielson, Bo G. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: European Journal of Haematology. - 0902-4441 .- 1600-0609. ; 58:3, s. 167-173
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l. Nine patients demonstrated a gradual increase in S-Epo levels, which reached a peak, and was accompanied by a parallel increase in S-TfR levels with a median lag period of 3 wk between both peaks. Hb correction followed the S-TfR peak after a second lag period (median 7 wk). Elevated S-Epo and S-TfR did not result in correction of anaemia in 1 patient due to impaired graft function. Within 4 months, S-Epo levels reached the normal range while TfR levels were higher than normal. Follow-up of iron status demonstrated the development of iron deficiency in 5 patients, which was corrected spontaneously. Improvement in erythropoiesis after renal transplantation seems to occur by means of expansion of the erythroid marrow, as detected by increasing S-TfR levels, subsequent to a S-Epo peak. This expansion precedes Hb normalization. A nonuraemic environment is probably a prerequisite for the correction of anaemia but not for the increase in S-Epo or S-TfR levels. Iron deficiency may occur after transplantation due to an increase in iron utilization.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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