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Th1 and Th2 cytokin...
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Pauksen, KarlisUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
Th1 and Th2 cytokine response after measles antigen stimulation in vitro in bone marrow transplant patients : response to measles vaccination
- Artikel/kapitelEngelska1997
Förlag, utgivningsår, omfång ...
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Springer Science and Business Media LLC,1997
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-55270
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55270URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1961654URI
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https://doi.org/10.1038/sj.bmt.1700903DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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In seronegative autologous bone marrow transplanted (ABMT) patients, a sustained cell-mediated immunity (CMI) has been shown to impair the antibody response after measles vaccination. To investigate if this might be caused by a preferential Th1 cytokine response, interferon (IFN)-gamma and interleukin (IL)-10 production of peripheral blood mononuclear cells (PBMC) was analyzed after measles antigen (M-ag) stimulation in vitro. The non-specific immune response was measured by IFN-alpha, and IL-12 analyses. Fifty non-vaccinated patients following ABMT or allogeneic bone marrow transplantation (BMT) were included. IFN-gamma production was significantly higher in patients with a retained CMI to measles than in patients without (2.3 vs 0.8 IU/ml; P = 0.01). Only a non-significant tendency was seen in IL-10 production (48.6 vs 26.7 pg/ml; NS), whereas no difference was found in IFN-alpha or IL-12 production. A positive correlation between IFN-gamma and IL-10 production was found (r(s) = 0.49; P < 0.001). After vaccination of 14 ABMT children, there was an increase in PBMC IFN-gamma production in vitro (2.5 vs <0.1 IU/ml; P < 0.05), whereas no changes were seen in the IL-10, IFN-alpha, or antibody levels. These results suggest that both Th1 and Th2 cytokine production are increased by M-ag stimulation in patients with a retained CMI to measles, but the Th1 response seems to be stronger. The preferential Th1 stimulation and increase in IFN-gamma production after vaccination may lead to a reduction in the humoral immune response which may explain the negative correlation between antibody production and T cell reactivity prior to vaccination.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sjölin, JanUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
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Linde, Annika
(författare)
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Alm, G.
(författare)
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Andersson, B.
(författare)
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Lönnerholm, GudmarUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Lönnerholm
(författare)
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Ljungman, PerKarolinska Institutet
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Bone Marrow Transplantation: Springer Science and Business Media LLC20:4, s. 317-3230268-33691476-5365
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