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Sökning: onr:"swepub:oai:DiVA.org:uu-58120" > Influence of segmen...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003892naa a2200349 4500
001oai:DiVA.org:uu-58120
003SwePub
008081017s2000 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-581202 URI
0247 a https://doi.org/10.1016/S0741-5214(00)70078-42 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hellberg, Andersu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular Surgery4 aut
2451 0a Influence of segmental spinal cord perfusion on intrathecal oxygen tension during experimental thoracic aortic crossclamping
264 1c 2000
338 a print2 rdacarrier
520 a PURPOSE: The purpose of this study was to evaluate the possibility of identifying alterations in blood supply to the spinal cord during thoracic aortic crossclamping.METHODS: In 17 pigs, a multiparameter PO(2), PCO(2,) and pH sensor was introduced into the intrathecal space for continuous monitoring of cerebrospinal fluid (CSF) oxygenation during aortic crossclamping. An epidural laser Doppler probe was used to measure spinal cord flux. After insertion of an aortic shunt from the left subclavian to the left iliac artery and interruption of the right subclavian and lumbar arteries (L2-L5), the thoracic aorta just distal to the left subclavian artery was clamped for 60 minutes. By placement of the distal aortic crossclamping below the level of L1 in group A (n = 9 animals), perfusion of only the abdominal visceral arteries was maintained. In group B (n = 8 animals), the distal aortic crossclamping was above the level of T12, and thus some spinal cord perfusion was maintained through the aortic shunt.RESULTS: The significant decrease in CSF PO(2) was observed within 3 minutes after the placement of the proximal aortic crossclamping and was normalized in all animals after establishment of the shunt flow. In group A, distal aortic crossclamping caused a decrease in CSF PO(2) with at least 50% of the preclamping values within 3 minutes. The mean CSF PO(2) of 2.99 +/- 0.70 kPa at 60 minutes of distal aortic crossclamping in group B was significantly higher than in group A (0.11 +/- 0.11 kPa; P <. 001). In group A, PCO(2) measurements showed no significant changes in 3 minutes after distal aortic crossclamping but revealed significantly higher values at 30 and 60 minutes compared with group B. Spinal cord flux values showed similar changes as CSF PO(2) during the whole experiment in both groups.CONCLUSION: In this experimental model of aortic crossclamping, continuous CSF oxygen tension monitoring allows rapid detection of alterations in spinal cord circulation.
653 a MEDICINE
653 a MEDICIN
7001 a Koga, Itaruu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut
7001 a Christiansson, Lennartu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut0 (Swepub:uu)lennchri
7001 a Stiernström, Hansu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut0 (Swepub:uu)hansstie
7001 a Wiklund, Larsu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)larswikl
7001 a Bergqvist, Davidu Uppsala universitet,Kärlkirurgi4 aut0 (Swepub:uu)daviberg
7001 a Karacagil, Sadettinu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular Surgery4 aut
7102 a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org
7730 t Journal of Vascular Surgeryg 31:1 Pt 1, s. 164-170q 31:1 Pt 1<164-170x 0741-5214
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-58120
8564 8u https://doi.org/10.1016/S0741-5214(00)70078-4

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