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Cloning and sequenc...
Cloning and sequencing of human gp330, a Ca2+ -binding receptor with potential intracellular signaling properties
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- Hjälm, Göran (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Murray, Edward (författare)
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Crumley, Gregg (författare)
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Harazim, William (författare)
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Lundgren, Stefan (författare)
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Onyango, Isaac (författare)
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Ek, Bo (författare)
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Larsson, Mårten (författare)
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- Juhlin, Claes (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Hellman, Per (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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Davis, Hughes (författare)
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- Åkerström, Göran (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Rask, Lars (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Morse, Buzzy (författare)
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(creator_code:org_t)
- Wiley, 1996
- 1996
- Engelska.
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Ingår i: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 239:1, s. 132-137
- Relaterad länk:
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https://febs.onlinel...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats. The deduced 4655 amino acid residues give a calculated molecular mass of 519636 Da for the mature protein and consists of a probable 25-amino-acid N-terminal signal peptide sequence, an extracellular region of 4398 amino acids, a single transmembrane-spanning domain of 23 amino acids, and an intracellular C-terminal region of 209 amino acid residues. Three types of cysteine-rich repeats characteristic of the low density lipoprotein receptor (LDLR) superfamily are present in human gp330. In the extracellular region, there are a total of 36 LDLR ligand-binding repeats, comprising four distinct domains, 16 growth factor repeats separated by eight YWTD spacer regions, and one epidermal growth factor-like repeat. No consensus cleavage sequence for the processing endoprotease furin is detected in human gp330. The intracellular tail contains not only two copies of the F(X)NPXY coated-pit mediated internalization signal characteristic of LDLR superfamily members, but also intriguing and potentially functional motifs including several Src-homology 3 recognition motifs, one Src-homology 2 recognition motif for the p85 regulatory subunit of phosphatidylinositol 3-kinase, and additional sites for protein kinase C, casein kinase II and cAMP-/cGMP-dependent protein kinase. There is approximately 77% amino acid identity between human and rat gp330 with minor differences between the extracellular and intracellular regions. Recently gp330 has been implicated in Ca2+ regulation in the parathyroid, the placenta, and the renal tubule, but its overall physiological and pathological role still remains uncertain.
Nyckelord
- Heymann nephritis
- calcium signaling
- cysteine repeats
- low-density-lipoprotein-receptor superfamily
- endocytic receptor
- MEDICINE
- MEDICIN
- NATURAL SCIENCES
- NATURVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hjälm, Göran
-
Murray, Edward
-
Crumley, Gregg
-
Harazim, William
-
Lundgren, Stefan
-
Onyango, Isaac
-
visa fler...
-
Ek, Bo
-
Larsson, Mårten
-
Juhlin, Claes
-
Hellman, Per
-
Davis, Hughes
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Åkerström, Göran
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Rask, Lars
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Morse, Buzzy
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visa färre...
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European Journal ...
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Uppsala universitet