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Nociceptin/orphanin...
Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe1)nociceptin(1-13)NH2
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Bytner, Beta (författare)
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Huang, Yan-Huang (författare)
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Yu, Long-Chuan (författare)
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Lundeberg, Thomas (författare)
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- Nylander, Ingrid (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology
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Rosén, Annika (författare)
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Brain Research. - 0006-8993 .- 1872-6240. ; 922:1, s. 118-124
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The present study investigated the effect of intraperiaqueductal grey injection of nociceptin/orphanin FQ (N/OFQ) and an antagonist (Nphe(1))nociceptin(1-13)NH(2) on the hindpaw withdrawal response to thermal and mechanical stimulation in rats. N/OFQ (5 nmol) significantly decreased the nociceptive thresholds in both tests and 1, 5 and 10 nmol of (Nphe(1))nociceptin(1-13)NH(2) significantly reversed this effect in a dose dependent way. Our results demonstrate, that N/OFQ has a nociceptive action, possibly through inhibition of PAG neurons. This effect is blocked by the antagonist (Nphe(1))nociceptin(1-13)NH(2) probably via ORL1 receptors in the periaqueductal grey.
Nyckelord
- nociceptin
- nociceptin antagonist
- nociception
- ORL-1 receptor
- periaqueductal grey
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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