Sökning: onr:"swepub:oai:DiVA.org:uu-64294" >
Feasibility of pall...
Feasibility of palladium catalysed isotopic exchange between [125I]iodide and 2-iodo-para-carborane
-
Eriksson, Ludvig (författare)
-
- Tolmachev, Vladimir (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
-
Sjöberg, Stefan (författare)
-
(creator_code:org_t)
- 2003-04-22
- 2003
- Engelska.
-
Ingår i: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 46:7, s. 623-631
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Many ortho-/meta-/para-closo-carborane derivatives have been proposed for boron neutron capture therapy. However, it is difficult to follow their pharmacokinetics in patients, which creates a risk of suboptimal treatment. Adding a radioactive label to closo-carboranes may simplify pharmacokinetic studies. This paper reports on a study of the feasibility of palladium-catalyzed isotopic exchange of iodinated closo-carborane with radioisotopes of iodine. 2-iodo-para-carborane was selected as a model compound. It was shown that such isotopic exchange is possible and provides a high yield (83±4.2%) after 40 min of reaction time. The reaction conditions were optimized, and it was demonstrated that the presence of tetra n-butylammonium hydrogensulfate is important in order to stabilize the catalyst and to give reproducibility of the labeling.
Nyckelord
- isotopic exchange
- 2-iodo-para-carborane
- [125I]iodide
- labeling
- palladium
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas