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Red-cell trapping i...
Red-cell trapping in the rat renal microcirculation induced by low-osmolar contrast media and mannitol
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- Nygren, A (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Hellberg, O (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Hansell, P (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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(creator_code:org_t)
- 1993
- 1993
- Engelska.
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Ingår i: Investigative Radiology. - 0020-9996 .- 1536-0210. ; 28:11, s. 1033-1038
- Relaterad länk:
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http://www.ncbi.nlm....
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Abstract
Ämnesord
Stäng
- RATIONALE AND OBJECTIVES: In acute renal failure after ischemia, intravascular obstruction by trapped red blood cells in the microvasculature of the renal outer medulla is a consistent finding. The influence of intravenously injected contrast media (CM) on such obstruction was investigated. METHODS: Anesthetized rats were subjected to 45 minutes of unilateral renal ischemia. Red-cell trapping in ischemically injured kidneys and in the contralateral uninjured kidneys was estimated from the intrarenal distribution of 51Cr-labelled erythrocytes after injection of ioxaglate or iopamidol in a dose of 1,600 mg I/kg body weight. As an osmolar control substance, mannitol (950 mOsm/kg) was given to a third group and isotonic Ringer's solution was administered to a fourth group. RESULTS: In the uninjured kidneys, treatment with ioxaglate or mannitol resulted in no red-cell trapping, while the iopamidol-treated group showed red-cell trapping in the inner stripe of the outer medulla in a dose-dependent manner. In the ischemically injured kidneys, both CM and mannitol enhanced the red-cell trapping in the inner stripe of the renal medulla. CONCLUSION: The results indicate that intravenously administered ioxaglate and iopamidol enhance the microvascular obstructions evoked by ischemic injury and that iopamidol may induce local impairment in renal medullary microcirculation in a normal kidney.
Nyckelord
- Animals
- Dose-Response Relationship; Drug
- Erythrocyte Volume/drug effects
- Erythrocytes/*drug effects
- Iopamidol/*pharmacology
- Ioxaglic Acid/*pharmacology
- Ischemia/*physiopathology
- Kidney/*blood supply
- Male
- Mannitol/*pharmacology
- Microcirculation
- Rats
- Rats; Sprague-Dawley
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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