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Relations of plasma...
Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures : the Framingham Heart Study.
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Evans, Jane C (författare)
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Benjamin, Emelia J (författare)
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Levy, Daniel (författare)
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Larson, Martin G (författare)
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Sawyer, Douglas B (författare)
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Siwik, Deborah A (författare)
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Colucci, Wilson S (författare)
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Sutherland, Patrice (författare)
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Wilson, Peter W F (författare)
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Vasan, Ramachandran S (författare)
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(creator_code:org_t)
- 2004
- 2004
- Engelska.
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Ingår i: Circulation. - 1524-4539. ; 109:23, s. 2850-6
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- BACKGROUND: Plasma levels of matrix metalloproteinase-9 (MMP-9), a key determinant of extracellular matrix degradation, are increased in heart failure and in acute coronary syndromes. We investigated cross-sectional relations of plasma MMP-9 to vascular risk factors and echocardiographic left ventricular (LV) measurements. METHODS AND RESULTS: We studied 699 Framingham Study participants (mean age, 57 years; 58% women), free of heart failure and previous myocardial infarction, who underwent routine echocardiography. We examined sex-specific distributions of LV internal dimensions (LVEDD) and wall thickness (LVWT) and sampled persons with both LVEDD and LVWT below the sex-specific median (referent, n=299), with increased LVEDD (LVEDD > or =90th percentile, n=204) and increased LVWT (LVWT > or =90th percentile, n=221) in a 3:2:2 ratio. Plasma MMP-9 was detectable in 138 persons (20%). In multivariable models, increasing heart rate (OR per SD, 1.41; 95% CI, 1.17 to 1.71) and antihypertensive treatment (OR, 1.63; 95% CI, 1.06 to 2.50) were key clinical correlates of detectable plasma MMP-9. In multivariable-adjusted models, detectable plasma MMP-9 was associated with increased LVEDD (OR, 2.84; 95% CI, 1.13 to 7.11), increased LVWT (OR, 2.54; 95% CI, 1.00 to 6.46), and higher LV mass (P=0.06) in men but not in women (OR for increased LVEDD, 1.37; 95% CI, 0.54 to 3.46; for increased LVWT, 0.99; 95% CI, 0.39 to 2.52; P=0.59 for LV mass). CONCLUSIONS: In our community-based sample, detectable plasma MMP-9 levels were associated with increased LV diastolic dimensions and increased wall thickness in men. These observations indicate that plasma MMP-9 level may be a marker for cardiac extracellular matrix degradation, a process involved in LV remodeling.
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Till lärosätets databas
- Av författaren/redakt...
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Sundström, Johan
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Evans, Jane C
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Benjamin, Emelia ...
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Levy, Daniel
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Larson, Martin G
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Sawyer, Douglas ...
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visa fler...
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Siwik, Deborah A
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Colucci, Wilson ...
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Sutherland, Patr ...
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Wilson, Peter W ...
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Vasan, Ramachand ...
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visa färre...
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Uppsala universitet