Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.

Nyckelord

Alanine/genetics

Amino Acid Substitution/genetics

Antithrombins/*chemistry/genetics/isolation & purification/metabolism

Arginine/*chemistry/genetics

Aspartic Acid/chemistry

Glutamic Acid/chemistry

Heparin/*metabolism

Humans

Ions/metabolism

Kinetics

Lysine/*chemistry/genetics

Oligosaccharides/*metabolism

Peptide Fragments/*chemistry/genetics/isolation & purification/metabolism

Protease Inhibitors/chemistry

Protein Binding/genetics

Protein Conformation

Protein Structure; Tertiary

Research Support; Non-U.S. Gov't

Research Support; U.S. Gov't; P.H.S.

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)