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Troponin T levels a...
Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome : prospective verification in the GUSTO-IV trial
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- James, Stefan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
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Armstrong, Paul (författare)
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Califf, Robert (författare)
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Simoons, Maarten L. (författare)
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- Venge, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Wallentin, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
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- Lindahl, Bertil (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: American Journal of Medicine. - 0002-9343 .- 1555-7162. ; 115:3, s. 178-184
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A third-generation troponin T assay with improved precision and a lower detection limit has been developed. However, the appropriate cutoff for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality has not been established. METHODS: A retrospective evaluation of data from the Fragmin and fast Revascularization during InStability in Coronary artery disease II (FRISC-II) trial suggested that a cutoff below 0.1 microg/L for troponin T levels might be more useful in risk stratification. A prospective validation of two cutoff levels (0.03 microg/L and 0.01 microg/L) was performed in 7115 patients with non-ST-elevation acute coronary syndrome from the Global Utilization of Strategies To open Occluded arteries IV (GUSTO-IV) trial. RESULTS: Patients with troponin T levels >0.1 microg/L had greater 30-day mortality (5.5% [201/3679]) than did those with levels CONCLUSION: Using a cutoff of
Nyckelord
- Acute Disease
- Aged
- Biological Markers/blood
- Coronary Disease/*blood/epidemiology
- Endpoint Determination/methods
- Europe/epidemiology
- Female
- Humans
- Male
- Myocardial Infarction/epidemiology
- North America/epidemiology
- Outcome Assessment (Health Care)
- Predictive Value of Tests
- Prospective Studies
- Reference Values
- Research Support; Non-U.S. Gov't
- Retrospective Studies
- Sensitivity and Specificity
- Survival Analysis
- Syndrome
- Troponin T/*blood
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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