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Src family kinase-i...
Src family kinase-inhibitor PP2 reduces focal ischemic brain injury
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- Lennmyr, Fredrik (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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Ericsson, A. (författare)
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- Gerwins, Pär (författare)
- Uppsala universitet,Institutionen för genetik och patologi,Enheten för radiologi,Nyman
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Akterin, S. (författare)
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi,Ahlström
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- Terént, Andreas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Hindawi Limited, 2004
- 2004
- Engelska.
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 110:3, s. 175-9
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To investigate the neuroprotective potential of the Src family kinase (SFK) inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo(3,4-d)pyrimidine (PP2) in transient focal cerebral ischemia in the rat. MATERIAL AND METHODS: Sprague-Dawley rats were exposed to transient (90 min) middle cerebral artery occlusion (MCAO) and evaluated after 1 day of survival. PP2 (1.5 mg/kg i.p.) or vehicle was given 30 min after MCAO. The lesions were examined with magnetic resonance imaging (MRI), tri-phenyl tetrazolium chloride (TTC) staining and the functional outcome was determined using neurological scoring according to Bederson et al. RESULTS: PP2-treated rats showed approximately 50% reduction of infarct size on T2-weighted MRI and in TTC staining compared with controls (P < 0.05). Moreover, the neurological score was better in the PP2 group than controls (P < 0.05). CONCLUSION: PP2 is a potential neuroprotective agent in cerebral ischemia-reperfusion. The interference of PP2 with SFKs and/or other pathways remains to be elucidated.
Nyckelord
- Animals
- Brain/*drug effects/enzymology/physiopathology
- Brain Ischemia/*drug therapy/enzymology/physiopathology
- Cerebral Infarction/drug therapy/enzymology/pathology
- Disease Models; Animal
- Infarction; Middle Cerebral Artery/*drug therapy/enzymology/physiopathology
- Magnetic Resonance Imaging
- Male
- Neuroprotective Agents/*pharmacology/therapeutic use
- Pyrimidines/*pharmacology/therapeutic use
- Rats
- Rats; Sprague-Dawley
- Recovery of Function/drug effects/physiology
- Research Support; Non-U.S. Gov't
- Tetrazolium Salts
- Treatment Outcome
- src-Family Kinases/*antagonists & inhibitors/metabolism
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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