onr:"swepub:oai:DiVA.org:uu-72693"
Sökning: onr:"swepub:oai:DiVA.org:uu-72693" > Increased dopamine ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03106naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-72693 | |
| 003 | SwePub | |
| 008 | 050527s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-726932 URI |
| 024 | 7 | a https://doi.org/10.1016/j.neulet.2003.11.0402 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kindlundh, Anna M Su Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)aki07668 |
| 245 | 1 0 | a Increased dopamine transporter density in the male rat brain following chronic nandrolone decanoate administration |
| 264 | 1 | b Elsevier BV,c 2004 |
| 338 | a print2 rdacarrier | |
| 520 | a Adolescent males currently employ anabolic-androgenic steroids (AAS) to become intoxicated, besides the traditional desires of an improved physical appearance and enhanced sports performance. Several studies indicate that AAS affect the brain reward system. Recently chronic administration with nandrolone decanoate to male rats has been shown to increase the dopamine transporter (DAT) density in the striatum visualised in vivo by positron emission tomography. The present study aimed to investigate if the increased DAT density could be confirmed using in vitro autoradiography following a comparable regimen of nandrolone treatment. Specific binding of 50 pM [125I] RTI-55 in the presence of 1 microM citalopram was used to label DAT. Two weeks of nandrolone decanoate administration at the supra-therapeutic doses 1, 5 and 15 mg/kg per day increased DAT density in the caudate putamen at all three doses. In conclusion, this study confirms that chronic nandrolone administration increases dopamine transporter density in the CPU and therefore supports the theory that AAS affects the dopamine system in the male rat brain. | |
| 653 | a Anabolic Agents | |
| 653 | a Animals | |
| 653 | a Autoradiography | |
| 653 | a Brain/drug effects/metabolism | |
| 653 | a Comparative Study | |
| 653 | a Male | |
| 653 | a Membrane Glycoproteins | |
| 653 | a Membrane Transport Proteins/*drug effects/metabolism | |
| 653 | a Nandrolone/*analogs & derivatives/*pharmacology | |
| 653 | a Nerve Tissue Proteins | |
| 653 | a Rats | |
| 653 | a Rats; Sprague-Dawley | |
| 653 | a Research Support; Non-U.S. Gov't | |
| 700 | 1 | a Rahman, Sadiau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)sarah838 |
| 700 | 1 | a Lindblom, Jonasu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)jli08577 |
| 700 | 1 | a Nyberg, Fredu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)frednybe |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
| 773 | 0 | t Neuroscience Lettersd : Elsevier BVg 356:2, s. 131-134q 356:2<131-134x 0304-3940x 1872-7972 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72693 |
| 856 | 4 8 | u https://doi.org/10.1016/j.neulet.2003.11.040 |
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