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Interaction between...
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Edlund, SofiaUppsala universitet,Ludwiginstitutet för cancerforskning
(författare)
Interaction between Smad7 and beta-catenin : importance for transforming growth factor beta-induced apoptosis
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-72728
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72728URI
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https://doi.org/10.1128/MCB.25.4.1475-1488.2005DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Members of the transforming growth factor beta (TGF-beta) and Wnt/wingless superfamilies regulate cell fate during development and tissue maintenance. Here we report that Smad7 interacts with beta-catenin and lymphoid enhancer binding factor 1/T-cell-specific factor (LEF1/TCF), transcriptional regulators in Wnt signaling, in a TGF-beta-dependent manner. Smad7 was found to be required for TGF-beta1-induced accumulation of beta-catenin and LEF1 in human prostate cancer (PC-3U) cells as well as in human keratinocytes (HaCaT cells). Moreover, when the endogenous Smad7 was repressed by specific small interfering RNA, TGF-beta-induced increase of activated p38, Akt phosphorylated on Ser473, glycogen synthase kinase 3beta phosphorylated on Ser9 was prevented, as well as the TGF-beta-induced association between beta-catenin and LEF1. Notably, the observed physical association of Smad7 and beta-catenin was found to be important for TGF-beta-induced apoptosis, since suppression of beta-catenin expression by small interfering RNA decreased the apoptotic response to TGF-beta.
Ämnesord och genrebeteckningar
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Animals
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Apoptosis/drug effects/*physiology
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COS Cells
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Cell Fractionation
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Cercopithecus aethiops
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Cytoskeletal Proteins/*metabolism
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DNA-Binding Proteins/*metabolism
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Glycogen Synthase Kinase 3/metabolism
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Humans
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Male
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Mice
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Phosphorylation/drug effects
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Prostatic Neoplasms/metabolism
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Protein Binding/drug effects
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Protein-Serine-Threonine Kinases/metabolism
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Proto-Oncogene Proteins/metabolism
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RNA; Small Interfering/metabolism
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Research Support; Non-U.S. Gov't
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Serine/metabolism
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Trans-Activators/*metabolism
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Transcription Factors/*metabolism
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Transforming Growth Factor beta/*pharmacology
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Tumor Cells; Cultured
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p38 Mitogen-Activated Protein Kinases/metabolism
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lee, So YoungUppsala universitet,Ludwiginstitutet för cancerforskning
(författare)
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Grimsby, SusanneUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)susagrim
(författare)
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Zhang, ShouthingUppsala universitet,Ludwiginstitutet för cancerforskning
(författare)
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Aspenström, PontusUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)pontaspe
(författare)
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Heldin, Carl-HenrikUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)carlheld
(författare)
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Landström, MaréneUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)mareland
(författare)
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Uppsala universitetLudwiginstitutet för cancerforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular and Cellular Biology25:4, s. 1475-14880270-73061098-5549
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