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Angiotensin convert...
Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients
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- Kurland, Lisa (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden, Department of Internal Medicine, Uppsala University Hospital, SE-751 85, Uppsala, Sweden
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Karlsson, Julia (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Kahan, Thomas (författare)
- Karolinska Institutet,Division of Internal Medicine, Karolinska Institute, Danderyd Hospital
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- Malmqvist, Karin (författare)
- Karolinska Institutet,Division of Internal Medicine, Karolinska Institute, Danderyd Hospital
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- Öhman, K. Peter (författare)
- Department of Medicine and Care, Faculty of Health Sciences, Linköping, Sweden
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- Nyström, Fredrik (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US
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- Hägg, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Hägg, A., Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2001
- 2001
- Engelska.
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 19:10, s. 1783-1787
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To determine whether polymorphisms in the renin-angiotensin system can predict blood pressure-lowering response to antihypertensive treatment; more specifically, in response to treatment with irbesartan or atenolol. DESIGN AND METHODS: Eighty-six patients with hypertension were randomized to double-blind treatment with either the angiotensin II type 1 receptor antagonist irbesartan or the beta1 adrenergic receptor blocker atenolol and followed for 3 months. We analysed angiotensinogen T174M and M235T, angiotensin converting enzyme (ACE) I/D and angiotensin II type 1 receptor A1166C polymorphisms and related them to blood pressure reduction. RESULTS: The mean reductions in blood pressure were similar for both treatments. In the irbesartan group, individuals homozygous for the ACE gene I allele showed a greater reduction in diastolic blood pressure, exceeding those with the D allele (-18 +/- 11 SD versus -7 +/- 10 mmHg, P = 0.0096). This was not the case during treatment with atenolol, and the interaction term between type of treatment and ACE II genotype was significant (P = 0.0176). The angiotensinogen and angiotensin II type 1 receptor polymorhisms were not related to the response to treatment. CONCLUSIONS: ACE genotyping predicted the blood pressure-lowering response to antihypertensive treatment with irbesartan but not atenolol. Thus, specific genotypes might predict the response to specific antihypertensive treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Adrenergic beta-Antagonists/therapeutic use
- Antihypertensive Agents/*therapeutic use
- Atenolol/therapeutic use
- Biphenyl Compounds/*therapeutic use
- Blood Pressure/*drug effects
- Double-Blind Method
- Female
- Forecasting
- Humans
- Hypertension/*drug therapy/*genetics
- Male
- Middle Aged
- Peptidyl-Dipeptidase A/*genetics
- Polymorphism; Genetic/*physiology
- Receptor; Angiotensin; Type 1
- Receptors; Angiotensin/*antagonists & inhibitors
- Research Support; Non-U.S. Gov't
- Tetrazoles/*therapeutic use
- Treatment Outcome
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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