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Insulin-mediated va...
Insulin-mediated vasodilatation, but not glucose uptake or endothelium-mediated vasodilatation, is enhanced in young females compared with males
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Fugmann, Andreas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Millgård, Jonas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och invärtesmedicin
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- Berne, Christian (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lithell, Hans (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 102:2, s. 241-246
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In order to evaluate possible differences between men and women with regard to the ability of insulin to induce vasodilatation, promote glucose uptake and enhance endothelium-dependent vasodilatation, 12 young (22-28 years), non-obese women and 15 corresponding males were subjected to 2 h of euglycaemic hyperinsulinaemia (insulin infusion rate of 56 m-units x min(-1) x m(-2)). Forearm blood flow was measured by venous occlusion plethysmography. Endothelium-dependent vasodilatation was evaluated by the local intra-arterial infusion of methacholine into the brachial artery (2-4 microg/min). The cardiac index was measured by thoracic bioimpedance. A 2 h period of hyperinsulinaemia increased the plasma insulin concentration to a similar degree in both sexes (females, 84 +/- 8.8 m-units/l; males, 87 +/- 7.5 m-units/l), but induced a more marked increase in forearm blood flow in females than in males (+104 +/- 67% and +52 +/- 30% respectively; P<0.01; 95% confidence interval for difference 11-94%). Furthermore, a significant decrease in total peripheral resistance (-20 +/- 6.9%; P<0.01) and an increase in cardiac index (+23 +/- 13%; P<0.01) were seen in women only (P<0.05 compared with men). Blood pressure and heart rate were not altered in either sex. Whole-body insulin-mediated glucose uptake and forearm glucose uptake did not differ between the sexes, and the ability of insulin to enhance endothelium-dependent vasodilatation (+19%; P<0.01) was similar in men and women. In conclusion, the present study shows that the ability of insulin to cause vasodilatation was greater in non-obese young women compared with men. However, no differences between the sexes were seen with regard to insulin-mediated glucose uptake and the ability of insulin to enhance endothelium-dependent vasodilatation.
Nyckelord
- Adult
- Brachial Artery/physiology
- Confidence Intervals
- Electric Impedance
- Endothelium; Vascular/*physiology
- Female
- Glucose/*metabolism
- Humans
- Hyperinsulinism/physiopathology
- Insulin/blood/*physiology
- Male
- Methacholine Chloride/diagnostic use
- Plethysmography
- Sex Characteristics
- Vascular Resistance/physiology
- Vasodilation/*physiology
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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