Sökning: onr:"swepub:oai:DiVA.org:uu-73216" >
Soluble intercellul...
Soluble intercellular adhesion molecule-1 is related to endothelial vasodilatory function in healthy individuals
-
Holmlund, A. (författare)
-
Hulthe, J. (författare)
-
- Millgård, Jonas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
-
visa fler...
-
- Sarabi, Mahziar (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och invärtesmedicin
-
Kahan, Thomas (författare)
-
- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
-
visa färre...
-
(creator_code:org_t)
- 2002
- 2002
- Engelska.
-
Ingår i: Atherosclerosis. - 0021-9150 .- 1879-1484. ; 165:2, s. 271-276
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To investigate the associations between markers of systemic and vascular inflammation, and indicators of vascular morphology and function. METHODS: In 59 apparently healthy individuals, we measured serum levels of highly sensitive C-reactive protein (hsCRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Endothelium-dependent (EDV) and -independent (EIDV) vasodilatation was evaluated in the forearm by venous occlusion plethysmography and local infusions of methacholine and sodium nitroprussid. Endothelial function index (EFI) was expressed as the EDV/EIDV ratio. The intima-media thickness (IMT) of the common carotid artery was investigated with ultrasound (far wall). RESULTS: EFI was inversely related only to ICAM-1 (r=-0.31, P<0.02) by univariate analysis. This association remained significant after adjustment for age, sex, blood pressure, smoking and serum cholesterol. EFI did not relate to hsCRP, VCAM-1 or E-selectin. Neither hsCRP, nor the adhesion molecules were significantly related to carotid artery IMT. CONCLUSION: ICAM-1 was related to endothelial vasodilatory function, but not to IMT, suggesting that endothelial inflammatory activation is related to an impaired vascular relaxation in apparently healthy individuals.
Nyckelord
- Adult
- Aged
- Biological Markers/*blood
- C-Reactive Protein/*metabolism
- Carotid Artery; Common/immunology
- E-Selectin/*blood
- Endothelium; Vascular/*immunology
- Female
- Humans
- Intercellular Adhesion Molecule-1/*blood
- Male
- Middle Aged
- Tunica Intima/anatomy & histology/immunology
- Vascular Cell Adhesion Molecule-1/*blood
- Vasodilation/*immunology
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas