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Platelet-derived gr...
Platelet-derived growth factor is angiogenic in vivo
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Risau, W (författare)
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Drexler, H (författare)
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Mironov, V (författare)
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Smits, Anja (författare)
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- Siegbahn, Agneta (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Funa, K (författare)
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Heldin, C H (författare)
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(creator_code:org_t)
- 1992
- 1992
- Engelska.
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Ingår i: Growth Factors. - 0897-7194 .- 1029-2292. ; 7:4, s. 261-266
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- PDGF receptors have recently been found to be expressed in microvascular endothelium in vivo under circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membrane in vivo. PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells. In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.
Nyckelord
- Allantois/blood supply
- Animals
- Brain/blood supply
- Capillaries/cytology
- Chemotaxis
- Chick Embryo
- Chorion/blood supply
- Comparative Study
- Endothelium; Vascular/cytology/physiology
- Macromolecular Substances
- Neovascularization; Pathologic
- Platelet-Derived Growth Factor/chemistry/*pharmacology
- Rats
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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