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Beta1-adrenergic re...
Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertension
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- Karlsson, Julia (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden; AstraZeneca Research and Development, Mölndal, Sweden
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- Hallberg, Pär (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Michaëlsson, Karl (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Ortopedi,Department of Surgical Sciences, Uppsala University, Uppsala
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- Kurland, Lisa, 1960- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Kahan, T. (författare)
- Karolinska Institutet
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- Malmqvist, K. (författare)
- Karolinska Institutet
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- Ohman, K. P. (författare)
- AstraZeneca Research and Development, Mölndal, Sweden; Department of Medicine and Care, Faculty of Health Sciences, Linköping, Sweden
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- Nyström, F. (författare)
- Department of Medicine and Care, Faculty of Health Sciences, Linköping, Sweden; Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping, Sweden
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,osteoporos,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Nystrom, E (författare)
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(creator_code:org_t)
- 2006-12-05
- 2004
- Engelska.
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 27:6, s. 347-350
- Relaterad länk:
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http://www.ncbi.nlm....
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Studies suggest that the Ser49Gly and Arg389Gly polymorphisms in the beta1-adrenergic receptor might be of functional importance for the cardiovascular system. Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo. HYPOTHESIS: The aim of this study was to test whether these polymorphisms were associated with the change in heart rate or blood pressure in patients with essential hypertension and left ventricular (LV) hypertrophy treated with the beta1-adrenergic receptor blocker atenolol. METHODS: Blood pressure and heart rate were measured in 101 hypertensive patients with echocardiographically verified LV hypertrophy, randomized in a double-blind study to treatment with either the beta1-adrenergic receptor blocker atenolol or the angiotensin II type I receptor antagonist irbesartan. Changes in blood pressure and heart rate were evaluated after 12 weeks. Beta1-adrenergic receptor genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: We found no significant associations between the changes in the measured variables and either of the two polymorphisms. However, carriers of the 49Gly allele showed a tendency toward a greater reduction in heart rate compared with patients with the Ser/Ser49 genotype (p = 0.06). CONCLUSIONS: The Ser49Gly and Arg389Gly beta1-adrenergic receptor polymorphisms do not seem to exert a major effect on the changes in heart rate and blood pressure during 12 weeks of treatment with atenolol in patients with essential hypertension and LV hypertrophy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adrenergic beta-Antagonists/*pharmacology
- Alleles
- Atenolol/*pharmacology
- Blood Pressure/drug effects
- Female
- Heart Rate/drug effects
- Humans
- Hypertension/*drug therapy/genetics/physiopathology
- Hypertrophy; Left Ventricular/*drug therapy/genetics/physiopathology
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism; Genetic
- Polymorphism; Restriction Fragment Length
- Receptors; Adrenergic; beta/drug effects/*genetics
- Research Support; Non-U.S. Gov't
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Karlsson, Julia
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Lind, Lars
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Hallberg, Pär
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Michaëlsson, Kar ...
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Kurland, Lisa, 1 ...
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Kahan, T.
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visa fler...
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Malmqvist, K.
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Ohman, K. P.
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Nyström, F.
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Melhus, Håkan
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Nystrom, E
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Clinical Cardiol ...
- Av lärosätet
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Uppsala universitet
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Örebro universitet
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Karolinska Institutet