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Folic acid suppleme...
Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis
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- Wentzel, Parri (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
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- Gäreskog, Mattias (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
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- Eriksson, Ulf J (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
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(creator_code:org_t)
- American Diabetes Association, 2005
- 2005
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:2, s. 546-553
- Relaterad länk:
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http://www.ncbi.nlm....
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visa fler...
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http://diabetes.diab...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Maternal administration of folic acid diminishes the risk of neural tube defects (NTDs) in offspring, but whether folic acid exerts a similar effect in diabetic pregnancy is unknown. The aim was to investigate whether maldevelopment in rat embryos caused by exposure to diabetes in vivo or high-glucose concentrations in vitro is affected by subcutaneous administration of folic acid to the pregnant mother or by adding the compound to the culture medium, respectively. Exposure of embryos to maternal diabetes in vivo or 30 mmol/l glucose in vitro yielded an increased malformation rate (71 and 88% NTD, respectively) and lowered somite number and crown-rump length compared with control embryos. When we injected folic acid into the diabetic pregnant rat, or added 2 mmol/l folic acid to the culture medium with high glucose, the embryonic parameters improved (3 and 5% NTD, respectively). The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy.
Nyckelord
- Abnormalities/*etiology/prevention & control
- Animals
- Diabetes Mellitus; Experimental/*pathology
- Dietary Supplements
- Female
- Folic Acid/*therapeutic use
- Glucose/*toxicity
- Neural Tube Defects/etiology/prevention & control
- Pregnancy
- Pregnancy in Diabetics/*physiopathology
- RNA/genetics/isolation & purification
- Rats
- Research Support; Non-U.S. Gov't
- Tail/abnormalities/embryology
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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