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The stem cell facto...
The stem cell factor receptor/c-Kit as a drug target in cancer
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- Lennartsson, Johan (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Rönnstrand, Lars (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Experimental Clinical Chemistry, Dept. of Laboratory Medicine, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Current Cancer Drug Targets. - 1568-0096 .- 1873-5576. ; 6:1, s. 65-75
- Relaterad länk:
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http://www.ncbi.nlm....
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http://www.ncbi.nlm.... (free)
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Abstract
Ämnesord
Stäng
- Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation and survival cues in tumor cells often occur as a consequence of unregulated tyrosine kinase activity. Much of the current development of anti-cancer therapies tries to target causative proteins in a specific manner to minimize side-effects. One attractive group of target proteins is the kinases. c-Kit is a receptor tyrosine kinase that normally controls the function of primitive hematopoietic cells, melanocytes and germ cells. It has become clear that uncontrolled activity of c-Kit contributes to formation of an array of human tumors. The unregulated activity of c-Kit may be due to overexpression, autocrine loops or mutational activation. This makes c-Kit an excellent target for cancer therapies in these tumors. In this review we will highlight the current knowledge on the signal transduction molecules and pathways activated by c-Kit under normal conditions and in cancer cells, and the role of aberrant c-Kit signaling in cancer progression. Recent advances in the development of specific inhibitors interfering with these signal transduction pathways will be discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Stem cell factor
- c-Kit
- receptor tyrosine kinase
- signal transduction
- transformation
- cancer
- leukemia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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