Sökning: onr:"swepub:oai:DiVA.org:uu-79106" > The genome sequence...
Fältnamn | Indikatorer | Metadata |
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000 | 03189naa a2200373 4500 | |
001 | oai:DiVA.org:uu-79106 | |
003 | SwePub | |
008 | 081017s1998 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-791062 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andersson, Siv GEu Uppsala universitet,Molekylärbiologi4 aut0 (Swepub:uu)san07069 |
245 | 1 0 | a The genome sequence of Rickettsia prowazekii and the origin of mitochondria |
264 | 1 | c 1998 |
338 | a print2 rdacarrier | |
500 | a Addresses: Kurland CG, Univ Uppsala, Dept Mol Biol, S-75124 Uppsala, Sweden. Univ Uppsala, Dept Mol Biol, S-75124 Uppsala, Sweden. Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. | |
520 | a We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. This genome contains 834 protein-coding genes. The functional profiles of these genes show similarities to those of mitochondrial genes: no genes required for anaerobic glycolysis are found in either R. prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in R. prowazekii. In effect, ATP production in Rickettsia is the same as that in mitochondria. Many genes involved in the biosynthesis and regulation of biosynthesis of amino acids and nucleosides in free-living bacteria are absent from R. prowazekii and mitochondria. Such genes seem to have been replaced by homologues in the nuclear (host) genome. The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. Such non-coding sequences may be degraded remnants of 'neutralized' genes that await elimination from the genome. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far. | |
650 | 7 | a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng |
700 | 1 | a Zomorodipour, Au Uppsala universitet,Molekylärbiologi4 aut |
700 | 1 | a Andersson, Jan Ou Uppsala universitet,Molekylärbiologi4 aut0 (Swepub:uu)janander |
700 | 1 | a Sicheritz-Ponten, Tu Uppsala universitet,Molekylärbiologi4 aut |
700 | 1 | a Alsmark, UCMu Uppsala universitet4 aut0 (Swepub:uu)cecialsm |
700 | 1 | a Podowski, RMu Uppsala universitet,Molekylärbiologi4 aut |
700 | 1 | a Näslund, A Kristinau Uppsala universitet,Molekylärbiologi4 aut0 (Swepub:uu)kna15246 |
700 | 1 | a Eriksson, Ann-Sofieu Uppsala universitet,Molekylärbiologi4 aut |
700 | 1 | a Winkler, HH4 aut |
700 | 1 | a Kurland, Charles Gu Uppsala universitet,Molekylärbiologi4 aut |
710 | 2 | a Uppsala universitetb Molekylärbiologi4 org |
773 | 0 | t Natureg 396:6707, s. 133-140q 396:6707<133-140x 0028-0836x 1476-4687 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79106 |
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