Sökning: onr:"swepub:oai:DiVA.org:uu-79630" > Family history of h...
Fältnamn | Indikatorer | Metadata |
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000 | 05227naa a2200781 4500 | |
001 | oai:DiVA.org:uu-79630 | |
003 | SwePub | |
008 | 060629s2005 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-15217 | |
009 | oai:prod.swepub.kib.ki.se:1935567 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-796302 URI |
024 | 7 | a https://doi.org/10.1093/jnci/dji2932 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152172 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19355672 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Chang, Ellen T.4 aut |
245 | 1 0 | a Family history of hematopoietic malignancy and risk of lymphoma |
264 | c 2005-10-05 | |
264 | 1 | b Oxford University Press (OUP),c 2005 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: A family history of hematopoietic malignancy is associated with an increased risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL), although the magnitude of the relative risk is unclear. We estimated the association between familial hematopoietic cancer and risk of lymphoma using validated, registry-based family data, and we also investigated whether associations between some environmental exposures and risk of lymphoma vary between individuals with and without such a family history. METHODS: In a population-based case-control study of malignant lymphoma, 1506 case patients and 1229 control subjects were linked to the Swedish Multi-Generation Register and then to the Swedish Cancer Register to ascertain history of cancer in first-degree relatives of patients with malignant lymphoma. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with the risk of lymphoma. RESULTS: A history of hematopoietic malignancy in any first-degree relative was associated with an increased risk of all NHL (OR = 1.8, 95% CI = 1.2 to 2.5), common B-cell NHL subtypes, and HL. Relative risks were generally stronger in association with sibling hematopoietic cancer (OR for all NHL = 3.2, 95% CI = 1.3 to 7.6) than with parental hematopoietic cancer (OR = 1.6, 95% CI = 1.1 to 2.3). A family history of NHL or chronic lymphocytic leukemia (CLL) was associated with an increased risk of several NHL subtypes and HL, whereas familial multiple myeloma was associated with a higher risk of follicular lymphoma. There was no statistically significant heterogeneity in NHL risk associations with environmental factors between individuals with and without familial hematopoietic malignancy. CONCLUSIONS: The increased risk of NHL and HL among individuals with a family history of hematopoietic malignancy was approximately twofold for both lymphoma types. There was no evidence that etiologic associations varied between familial NHL and nonfamilial NHL. | |
653 | a Adult | |
653 | a Aged | |
653 | a Case-Control Studies | |
653 | a Confidence Intervals | |
653 | a Environmental Exposure/adverse effects | |
653 | a Female | |
653 | a Genetic Predisposition to Disease | |
653 | a Hematologic Neoplasms/*genetics | |
653 | a Hodgkin Disease/*epidemiology/etiology/*genetics | |
653 | a Humans | |
653 | a Incidence | |
653 | a Leukemia; Lymphocytic; Chronic/genetics | |
653 | a Logistic Models | |
653 | a Lymphoma; Follicular/genetics | |
653 | a Lymphoma; Non-Hodgkin/*epidemiology/etiology/*genetics | |
653 | a Male | |
653 | a Medical Record Linkage | |
653 | a Middle Aged | |
653 | a Multiple Myeloma/genetics | |
653 | a Odds Ratio | |
653 | a Registries | |
653 | a Research Support; N.I.H.; Extramural | |
653 | a Research Support; Non-U.S. Gov't | |
653 | a Research Support; U.S. Gov't; P.H.S. | |
653 | a Risk Assessment | |
653 | a Risk Factors | |
653 | a Sweden/epidemiology | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Ekström Smedby, Karinu Karolinska Institutet4 aut |
700 | 1 | a Hjalgrim, Henriku Karolinska Institutet4 aut |
700 | 1 | a Porwit-MacDonald, Annau Karolinska Institutet4 aut |
700 | 1 | a Roos, Göranu Umeå universitet,Patologi4 aut0 (Swepub:umu)goro0001 |
700 | 1 | a Glimelius, Bengtu Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)bengglim |
700 | 1 | a Adami, Hans-Olov4 aut |
710 | 2 | a Karolinska Institutetb Patologi4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 97:19, s. 1466-1474q 97:19<1466-1474x 0027-8874x 1460-2105 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16204696&dopt=Citation |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/97/19/1466/7686630/dji293.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79630 |
856 | 4 8 | u https://doi.org/10.1093/jnci/dji293 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-15217 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1935567 |
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