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Phase II study of c...
Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer.
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-81295
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-81295URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle of oral capecitabine (1000 mg m(-2) twice daily, days 1-14) plus i.v. paclitaxel (175 mg m(-2), day 1) in anthracycline-pretreated advanced/MBC. In all, 73 patients were enrolled at 13 Swedish and Spanish centres. The objective response rate was 52% (95% confidence interval (CI): 40-63%) in the intent-to-treat population, including complete responses in 11%. Disease was stabilised in a further 29%. The median time to disease progression (TTP) was 8.1 months and the median overall survival was 16.5 months. The combination was generally well tolerated with a predictable safety profile. The most common treatment-related nonhaematological adverse events were hand-foot syndrome (42%), alopecia (30%) and diarrhoea (26%). The only treatment-related Grade 3/4 adverse events occurring in >5% of patients were alopecia (22%) and hand-foot syndrome (11%). Grade 3/4 neutropenia and lymphocytopenia were reported in 12 and 14% of patients, respectively. Capecitabine plus paclitaxel is highly active with a favourable safety profile in anthracycline-pretreated MBC.
Ämnesord och genrebeteckningar
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Adolescent
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Adult
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Aged
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Anthracyclines/therapeutic use
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Antineoplastic Agents/therapeutic use
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Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
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Breast Neoplasms/*drug therapy/mortality
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Deoxycytidine/administration & dosage/adverse effects/*analogs & derivatives
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Disease Progression
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Female
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Humans
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Maximum Tolerated Dose
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Middle Aged
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Paclitaxel/administration & dosage/adverse effects
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Survival Rate
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Treatment Outcome
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Perez-Manga, G
(författare)
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Constenla, M
(författare)
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Ruiz, A
(författare)
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Carabantes, F
(författare)
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Castellanos, J
(författare)
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Gonzalez Baron, M
(författare)
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Villman, K
(författare)
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Söderberg, M
(författare)
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Ahlgren, JUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Centrum för klinisk forskning, Gävleborg
(författare)
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Casinello, J
(författare)
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Regueiro, P
(författare)
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Murias, A
(författare)
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Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Br J Cancer90:9, s. 1740-60007-0920
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Batista, N
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Perez-Manga, G
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Constenla, M
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Ruiz, A
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Carabantes, F
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Castellanos, J
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visa fler...
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Gonzalez Baron, ...
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Villman, K
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Söderberg, M
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Ahlgren, J
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Casinello, J
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Regueiro, P
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Murias, A
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visa färre...
- Artiklar i publikationen
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Br J Cancer
- Av lärosätet
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Uppsala universitet