Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

• The structures of human glyoxalase I in complexes with S-(N-hydroxy-N-p-iodophenylcarbamoyl)glutathione (HIPC-GSH) and S-p-nitrobenzyloxycarbonylglutathione (NBC-GSH) have been determined at 2.0 and 1.72 Angstrom resolution, respectively. HIPC-GSH is a tr

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ACTIVE-SITE; TRIOSEPHOSPHATE ISOMERASE; SUBSTRATE USAGE; REFINEMENT; SYSTEM; METAL; NMR; DERIVATIVES; INHIBITORS; RESONANCE

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