Sökning: onr:"swepub:oai:DiVA.org:uu-89897" > Elevated levels of ...
Fältnamn | Indikatorer | Metadata |
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000 | 02819naa a2200337 4500 | |
001 | oai:DiVA.org:uu-89897 | |
003 | SwePub | |
008 | 020510s1996 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-898972 URI |
024 | 7 | a https://doi.org/10.1111/1523-1747.ep123296122 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andersson, Ann-Catrinu Uppsala universitet,Institutionen för patologi4 aut |
245 | 1 0 | a Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands |
264 | 1 | b Elsevier BV,c 1996 |
338 | a print2 rdacarrier | |
520 | a ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent. | |
700 | 1 | a Merza, Malik4 aut |
700 | 1 | a Venables, Patrick JW4 aut |
700 | 1 | a Pontén, Fredriku Uppsala universitet,Institutionen för patologi4 aut0 (Swepub:uu)fredpont |
700 | 1 | a Sundström, Johanu Uppsala universitet,Institutionen för patologi4 aut |
700 | 1 | a Cohen, Maurice4 aut |
700 | 1 | a Larsson, Eriku Uppsala universitet,Institutionen för patologi4 aut0 (Swepub:uu)eriklars |
710 | 2 | a Uppsala universitetb Institutionen för patologi4 org |
773 | 0 | t Journal of Investigative Dermatologyd : Elsevier BVg 106:1, s. 125-128q 106:1<125-128x 0022-202Xx 1523-1747 |
856 | 4 | u https://doi.org/10.1111/1523-1747.ep12329612 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89897 |
856 | 4 8 | u https://doi.org/10.1111/1523-1747.ep12329612 |
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