SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-90230"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-90230" > Transepidermal wate...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003227naa a2200397 4500
001oai:DiVA.org:uu-90230
003SwePub
008030416s2003 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1949165
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-902302 URI
0247 a https://doi.org/10.1203/01.PDR.0000055777.25933.982 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19491652 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ågren, Johanu Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut0 (Swepub:uu)johaagre
2451 0a Transepidermal water loss in developing rats :b Role of aquaporins in the immature skin
264 1c 2003
338 a print2 rdacarrier
520 a In the extremely preterm infant, high transepidermal water loss (TEWL) can result in severe dehydration. TEWL has been attributed to the structural properties of the epidermis but might also be influenced by mechanisms that facilitate water transport. To investigate whether aquaporins (AQP) may be involved in the extreme losses of water through immature skin, we examined the presence and cellular distributions of AQP-1 and AQP-3 in embryonic and adult rat skin by immunohistochemistry. The expression of AQP mRNA in skin was analyzed with the use of semiquantitative reverse transcription-PCR. In rat pups of different embryonic (E) and postnatal (P) ages (days), TEWL and skin hydration were measured. AQP-1 was detected in dermal capillaries, and AQP-3 was abundant in basal epidermal layers. Both AQP displayed several times higher expression in embryonic than in adult skin. TEWL was highest at embryonic day 18 (E18) (133 +/- 18 g/m2h) and lower at E20 (25 +/- 1 g/m2h) and P4 (9 +/- 2 g/m2h). Skin hydration measured as skin electrical capacitance paralleled TEWL, being highest in fetal skin (794 +/- 15 pF at E18) and decreasing to 109 +/- 11 pF at E20 and to 0 +/- 0 pF at P4. We conclude that, as in infants, water loss through the skin of rats decreases markedly with maturation during the perinatal period. The expression and cellular localization of the AQP are such that they might influence skin hydration and water transport and contribute to the high losses of water through the immature skin.
653 a MEDICINE
653 a MEDICIN
7001 a Zelenin, Sergeyu Karolinska Institutet4 aut
7001 a Håkansson, Mattias4 aut
7001 a Eklöf, Ann-Christine4 aut
7001 a Aperia, Anitau Karolinska Institutet4 aut
7001 a Nejsum, Lene N.4 aut
7001 a Nielsen, Sören4 aut
7001 a Sedin, Gunnaru Perinatal, neonatal och barnkardiologisk forskning/Sedin4 aut0 (Swepub:uu)gunsedin
7102 a Uppsala universitetb Institutionen för kvinnors och barns hälsa4 org
7730 t Pediatric Researchg 53:4, s. 558-565q 53:4<558-565x 0031-3998x 1530-0447
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-90230
8564 8u https://doi.org/10.1203/01.PDR.0000055777.25933.98
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1949165

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy