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Vitamin C, diclophe...
Vitamin C, diclophenac and L-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humans
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- Steer, Peter (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Millgård, Jonas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Lithell, Hans (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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- Vessby, Bengt (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Berne, Christian (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Atherosclerosis. - 0021-9150 .- 1879-1484. ; 168:1, s. 65-72
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- An acute elevation of circulating non-esterified fatty acids (NEFAs) has previously been shown to impair endothelium-dependent vasodilation (EDV). In this study, we investigated if local administration of vitamin C (n=8, 18 mg/min), L-arginine (n=8, 12.5 mg/min), or the cyclooxygenase (COX) inhibitor diclophenac (n=8, 0.5 mg/min) can counteract the endothelial dysfunction seen during infusion of Intralipid plus heparin (n=10). EDV and endothelium-independent vasodilation (EIDV) were studied in the forearm after local administration of methacholine chloride (Mch; 2 and 4 microg/min) and sodium nitroprusside (SNP; 5 and 10 microg/min). Forearm blood flow (FBF) was determined with venous occlusion plethysmography. Intralipid and heparin increased circulating NEFA levels sevenfold and impaired EDV (P<0.001 vs baseline). Concomitant administration of L-arginine or diclophenac abolished the NEFA-induced impairment in EDV. Concomitant vitamin C administration actually improved EDV (P<0.05 vs baseline). NEFA elevation increased EIDV (P<0.01), but this effect was not significant after L-arginine or diclophenac infusions. In conclusion, an acute elevation of circulating NEFAs led to impaired EDV. Administration of L-arginine, vitamin C or COX inhibition abolished this effect, suggesting that NEFAs might interact with endothelial vasodilatory function through multiple mechanisms.
Nyckelord
- Adult
- Anticoagulants/pharmacology
- Arginine/*pharmacology
- Ascorbic Acid/*pharmacology
- Comparative Study
- Cyclooxygenase Inhibitors/*pharmacology
- Diclofenac/*pharmacology
- Endothelium; Vascular/*drug effects/*physiology
- Fat Emulsions; Intravenous/pharmacology
- Fatty Acids; Nonesterified/blood/*metabolism
- Female
- Forearm/blood supply
- Free Radical Scavengers/*pharmacology
- Heparin/pharmacology
- Humans
- Infusions; Intravenous
- Male
- Reference Values
- Regional Blood Flow/drug effects/physiology
- Sweden
- Tocopherols/blood
- Triglycerides/metabolism
- Vasodilation/*drug effects/*physiology
- alpha-Linolenic Acid/metabolism
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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