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Synthesis and Radio...
Synthesis and Radioiodination of 7-(3´-Ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), (ANC)
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- Ghirmai, Senait (författare)
- Uppsala universitet,Kemiska institutionen
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- Malmquist, Jonas (författare)
- Uppsala universitet,Kemiska institutionen
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- Lundquist, Hans (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Tolmachev, Vladimir (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Sjöberg, Stefan (författare)
- Uppsala universitet,Kemiska institutionen
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(creator_code:org_t)
- 2004-08-12
- 2004
- Engelska.
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Ingår i: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 47:9, s. 557-569
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Derivatives of nido-carborate have potential use in tumour targeting as hydrophilic boron-rich compounds for boron neutron capture therapy (BNCT) and as pendant groups for attachment of radiohalogens to tumour-seeking molecules. For this purpose, functionalized derivatives of nido-carborates that can be conjugated to biomolecules should be synthesized and evaluated. In this study, racemic 1, 7-(3′-ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1) (acronym ANC) was obtained by degradation of the corresponding aminopropyl-o-carborane, which was synthesized in three steps from 1-tert-butyldimethylsilyl-2-(3-bromopropyl)-o-carborane, with sodium hydroxide in absolute ethanol. The racemate 1 was radioiodinated (125I) using the Chloramine-T method. Radio-TLC results showed that radiolabelling with 125I was achieved in a yield greater than 95%.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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