Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats

• Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Nyckelord

Administration; Oral

Animals

Antigens; CD8/metabolism

Antigens; Differentiation/metabolism

Chronic Disease

Cytokines/metabolism

Enzyme-Linked Immunosorbent Assay/methods

Flow Cytometry/methods

Gene Expression Regulation/physiology

Humans

Hypersensitivity; Delayed/etiology/immunology

Male

Peyer's Patches/immunology/metabolism

Rats

Rats; Wistar

Serum Albumin/administration & dosage/*immunology

Starch/*administration & dosage/immunology

Stress; Psychological/*immunology/pathology

Time Factors

MEDICINE

MEDICIN

PHARMACY

FARMACI

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)