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Active smoking and ...
Active smoking and a history of smoking are associated with enhanced prostaglandin F(2alpha), interleukin-6 and F(2)-isoprostane formation in elderly men
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- Helmersson, Johanna (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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- Larsson, Anders (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Vessby, Bengt (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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- Basu, Samar (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 181:1, s. 201-207
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The underlying mechanisms by which smoking induces cardiovascular diseases are largely unknown. The effect of smoking status on the cyclooxygenase (COX)-mediated inflammatory indicator prostaglandin F(2alpha) (PGF(2alpha)) has never been studied. Associations of cytokines and antioxidants and smoking status, have shown conflicting results. Urinary 15-keto-dihydro-PGF(2alpha) (a major metabolite of PGF(2alpha)), serum interleukin-6 (IL-6) and high sensitivity C-reactive protein (hsCRP), serum amyloid protein A (SAA), urinary 8-iso-PGF(2alpha) (an F(2)-isoprostane, indicator of oxidative stress), and serum alpha-tocopherol were quantified in a population-based sample (n = 642) of 77-year old men without diabetes. Fifty-five men were current smokers and 391 former smokers. Inflammatory indicators were increased in current smokers (15-keto-dihydro-PGF(2alpha), P < 0.001; IL-6, P = 0.01) than non-smokers. 8-iso-PGF(2alpha) was increased (P < 0.01) and alpha-tocopherol reduced (P < 0.001) in current smokers. Further, former smokers had increased formation of 15-keto-dihydro-PGF(2alpha), IL-6 and 8-iso-PGF(2alpha) compared non-smokers. This is the first study to show that smokers have increased PGF(2alpha) formation, thus enhanced COX-mediated inflammation, in addition to elevated levels of cytokines and isoprostanes. Subclinical COX- and cytokine-mediated inflammation and oxidative stress are ongoing processes not only in active smokers but also in former smokers which may contribute to the accelerated atherosclerosis associated with smoking.
Nyckelord
- Aged
- Aging/*metabolism
- Antioxidants/metabolism
- Biological Markers/blood/urine
- C-Reactive Protein/metabolism
- Cohort Studies
- Cytokines/metabolism
- Dinoprost/analogs & derivatives/*biosynthesis/urine
- F2-Isoprostanes/*biosynthesis
- Humans
- Inflammation/etiology
- Interleukin-6/*biosynthesis/blood
- Longitudinal Studies
- Male
- Oxidative Stress
- Prostaglandin-Endoperoxide Synthases/metabolism
- Smoking/*adverse effects
- Smoking Cessation
- Time Factors
- Tocopherols/blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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