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Serum selenium pred...
Serum selenium predicts levels of F2-isoprostanes and prostaglandin F2alpha in a 27 year follow-up study of Swedish men
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- Helmersson, Johanna (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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- Ärnlöv, Johan (författare)
- Uppsala universitet,Geriatrik
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- Vessby, Bengt (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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Alfthan, Georg (författare)
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- Basu, Samar (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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(creator_code:org_t)
- 2009-07-07
- 2005
- Engelska.
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Ingår i: Free radical research. - : Informa UK Limited. - 1071-5762 .- 1029-2470. ; 39:7, s. 763-770
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Low concentrations of selenium (Se) predict mortality and cardiovascular diseases in some populations. The effect of Se on in vivo indicators of oxidative stress and inflammation, two important features of atherosclerosis, in human populations is largely unexplored. This study investigated the longitudinal association between serum selenium (s-Se) and a golden standard indicator of oxidative stress in vivo (8-iso-prostaglandin F2, a major F2-isoprostane), an indicator of cyclooxygenase (COX)-mediated inflammation (prostaglandin F2), high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years. The s-Se was measured in 615 Swedish men at 50 years of age in a health investigation. The status of oxidative stress and inflammation was evaluated in a re-investigation 27 years later by quantification of urinary 8-iso-PGF2 and 15-keto-dihydro- PGF2 (a major metabolite of PGF2) and serum hsCRP, SAA and IL-6. Men in the highest quartile of s-Se at age 50 had decreased levels of 8-iso-PGF2 compared to all lower quartiles and decreased levels of PGF2 compared to all lower quartiles at follow-up. These associations were independent of BMI, diabetes, hyperlipidemia, hypertension, smoking, -tocopherol and β-carotene at baseline. The s-Se was not associated with hsCRP, SAA or IL-6 at follow-up. In conclusion, high concentrations of s-Se predict reduced levels of oxidative stress and subclinical COX-mediated (but not cytokine-mediated) inflammation in a male population. The associations between Se, oxidative stress and inflammation, respectively, might be related to the proposed cardiovascular protective property of Se.
Nyckelord
- Aged
- Biological Markers/blood/urine
- C-Reactive Protein/metabolism
- Cardiovascular Diseases/blood/epidemiology/urine
- Cohort Studies
- Diet
- Dinoprost/*analogs & derivatives/urine
- Follow-Up Studies
- Humans
- Inflammation/blood
- Inflammation Mediators/blood
- Interleukin-6/blood
- Isoprostanes/*pharmacology
- Longitudinal Studies
- Male
- Middle Aged
- Oxidative Stress
- Radioimmunoassay
- Selenium/administration & dosage/*blood
- Serum Amyloid A Protein/metabolism
- Sweden/epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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