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Deletion rate evolu...
Deletion rate evolution and its effect on genome size and coding density
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- Pettersson, Mats (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för evolution, genomik och systematik,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Kurland, Charles (författare)
- Lund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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- Berg, Otto G. (författare)
- Uppsala universitet,Molekylär evolution
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(creator_code:org_t)
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- 2009-03-18
- 2009
- Engelska.
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Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 26:6, s. 1421-1430
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Abstract
Ämnesord
Stäng
- Deletion rates are thought to be important factors in determining the genome size of organisms in nature. Although it is indisputable that deletions, and thus deletion rates, affect genome size, it is unclear how, or indeed if, genome size is regulated via the deletion rate. Here, we employ a mathematical model to determine the evolutionary fate of deletion rate mutants. Simulations are employed to explore the interactions between deletions, deletion rate mutants, and genome size. The results show that, in this model, the fate of deletion rate mutants will depend on the fraction of essential genomic material, on the frequency of sexual recombination, as well as on the population size of the organism. We find that there is no optimal deletion rate in any state. However, at one critical coding density, all changes in deletion rate are neutral and the rate may drift either up or down. As a consequence, the coding density of the genome is expected to fluctuate around this critical density. Characteristic differences in the impact of deletion rate mutations on prokaryote and eukaryote genomes are described.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- genome size
- junk DNA
- insertion-deletion dynamics
- deletion bias
- modifier evolution
- Biology
- Biologi
- modifier evolution
- deletion bias
- insertion-deletion dynamics
- genome size
- junk DNA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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