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T cell control of p...
T cell control of primary and latent cytomegalovirus infections in healthy subjects
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- Lidehäll, Anna Karin, 1975- (författare)
- Uppsala universitet,Enheten för klinisk immunologi,Olle Korsgren
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- Sund, Fredrik (författare)
- Divisions of Infectious Diseases, University Hospital, Uppsala, Sweden,Friman, infektion
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- Lundberg, Tobias (författare)
- Divisions of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden
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- Eriksson, Britt-Marie (författare)
- Divisions of Infectious Diseases, University Hospital, Uppsala, Sweden,Friman, infektion
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- Tötterman, Thomas H. (författare)
- Divisions of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden
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- Korsgren, Olle (författare)
- Divisions of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2005
- 2005
- Engelska.
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Ingår i: Journal of Clinical Immunology. - : Springer Science and Business Media LLC. - 0271-9142 .- 1573-2592. ; 25:5, s. 473-481
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The T cell repertoire required to control acute and latent CMV infection in otherwise healthy individuals was examined using both functional analysis and a wide range of MHC I tetramers. Both frequency and function of CMV specific T cells varied considerably between subjects, however, within subjects values remained stable over time. In total 16 ± 3.5 CMV specific T cells/μl blood was detected, with obvious immunodominance between different CMV epitopes. Most subjects with latent infection showed low CMV specific T cell activity, whereas a subgroup (1/3) of individuals was high in either frequency or function of their CMV specific T cells. Patients with acute infection displayed high initial, but rapidly decreasing, numbers of CMV specific cells. In conclusion, a majority of healthy individuals readily seem to control latent CMV infection, whereas a subpopulation (1/3) of individuals uses a large proportion of their CD8+ T cell repertoire to control the infection.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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