Sökning: onr:"swepub:oai:DiVA.org:uu-97804" > Does APOE explain t...
Fältnamn | Indikatorer | Metadata |
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000 | 03760naa a2200589 4500 | |
001 | oai:DiVA.org:uu-97804 | |
003 | SwePub | |
008 | 081121s2008 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:117572934 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-978042 URI |
024 | 7 | a https://doi.org/10.1002/ajmg.b.306812 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1175729342 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Blom, Elin Susanneu Uppsala universitet,Geriatrik4 aut |
245 | 1 0 | a Does APOE explain the linkage of Alzheimer’s disease to chromosome 19q13? |
264 | c 2007-12-27 | |
264 | 1 | b Wiley,c 2008 |
338 | a print2 rdacarrier | |
520 | a We have studied the impact of the apolipoprotein E gene (APOE) on the chromosome 19 linkage peak from an analysis of sib-pairs affected by Alzheimer's disease. We genotyped 417 affected sib-pairs (ASPs) collected in Sweden and Norway (SWE), the UK and the USA for 10 microsatellite markers on chromosome 19. The highest Zlr (3.28, chromosome-wide P-value 0.036) from the multi-point linkage analysis was located approximately 1 Mb from APOE, at marker D19S178. The linkage to chromosome 19 was well explained by APOE in the whole sample as well as in the UK and USA subsamples, as identity by descent (IBD) increased with the number of epsilon 4 alleles in ASPs. There was a suggestion from the SWE subsample that linkage was higher than would be expected from APOE alone, although the test for this did not reach formal statistical significance. There was also a significant age at onset (aao) effect on linkage to chromosome 19q13 in the whole sample, which manifested itself as increased IBD sharing in relative pairs with lower mean aao. This effect was partially, although not completely, explained by APOE. The aao effect varied considerably between the different subsamples, with most of the effect coming from the UK sample. The other samples showed smaller effects in the same direction, but these were not significant. | |
653 | a Alzheimer's disease | |
653 | a APOE | |
653 | a linkage | |
653 | a age at onset | |
653 | a apolipoprotein E | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Holmans, Peter4 aut |
700 | 1 | a Arepalli, Sampath4 aut |
700 | 1 | a Adighibe, Omanma4 aut |
700 | 1 | a Hamshere, Marian L.4 aut |
700 | 1 | a Gatz, Margaret4 aut |
700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
700 | 1 | a Bergem, A. L. Mina4 aut |
700 | 1 | a Owen, Michael J.4 aut |
700 | 1 | a Hollingworth, Paul4 aut |
700 | 1 | a Goate, Alison4 aut |
700 | 1 | a Williams, Julie4 aut |
700 | 1 | a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021 |
700 | 1 | a Hardy, John4 aut |
700 | 1 | a Wavrant-De Vrièze, Fabienne4 aut |
700 | 1 | a Glaser, Annau Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)angla622 |
710 | 2 | a Uppsala universitetb Geriatrik4 org |
773 | 0 | t American Journal of Medical Genetics Part B: Neuropsychiatric Genetics American Journal of Medical Genetics Part B: Neuropsychiatric Geneticsd : Wileyg 147B:6, s. 778-83q 147B:6<778-83x 1552-485X |
773 | 0 | t American Journal of Medical Genetics Part B: Neuropsychiatric Geneticsd : Wileyg 147B:6, s. 778-83q 147B:6<778-83x 1552-4841 |
856 | 4 | u https://europepmc.org/articles/pmc2726752?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97804 |
856 | 4 8 | u https://doi.org/10.1002/ajmg.b.30681 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:117572934 |
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