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Antimalarial resist...
Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania.
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- Eriksen, J (författare)
- Karolinska Institutet
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Mwankusye, S (författare)
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Mduma, S (författare)
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- Veiga, M I (författare)
- Karolinska Institutet
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Kitua, A (författare)
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- Tomson, G (författare)
- Karolinska Institutet
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- Petzold, M G (författare)
- Karolinska Institutet
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- Swedberg, Göte (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Gustafsson, L L (författare)
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Warsame, M (författare)
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(creator_code:org_t)
- Oxford University Press (OUP), 2008
- 2008
- Engelska.
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Ingår i: Transactions of the Royal Society of Tropical Medicine and Hygiene. - : Oxford University Press (OUP). - 0035-9203 .- 1878-3503. ; 102:2, s. 137-142
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We assessed the efficacy of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) and DHFR/DHPS genotypes of Plasmodium falciparum in rural Tanzania, 3 years after their introduction as first- and second-line treatments for uncomplicated malaria, respectively. Under five children with uncomplicated malaria were given standard treatments of either SP (n=66) or AQ (n=30) and treatment outcomes after 14 and 28 days were determined. Total treatment failure of 18 and 42.5% was observed for SP on days 14 and 28, respectively. For AQ, total treatment failure of 27 and 53% was found on day 14 and 28, respectively. On day 14, significantly lower SP total treatment failures were observed in 2004 compared with results from a study conducted in 1999 in the same location. No relationship was detected between clinical outcome and DHFR/DHPS genotypes, but the point mutation prevalence in parasites was higher than in 1999. Pre-treatment blood levels of SP were detected in a quarter of the study children: less than expected. We report unacceptably high levels of total treatment failures, both for first- and second-line treatments for uncomplicated malaria in Tanzania 3 years after their introduction, supporting the decision to replace them with artemisinin-based combination therapy.
Nyckelord
- Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Eriksen, J
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Mwankusye, S
-
Mduma, S
-
Veiga, M I
-
Kitua, A
-
Tomson, G
-
visa fler...
-
Petzold, M G
-
Swedberg, Göte
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Gustafsson, L L
-
Warsame, M
-
visa färre...
- Artiklar i publikationen
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Transactions of ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet