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Association between...
Association between serum cathepsin S and mortality in older adults
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- Jobs, Elisabeth (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Ingelsson, Erik (författare)
- Karolinska Institutet,Uppsala universitet,Geriatrik
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Nerpin, Elisabet (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Jobs, Magnus (författare)
- Högskolan Dalarna,Medicinsk vetenskap
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (författare)
- Uppsala universitet,Oxidativ stress och inflammation
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- Larsson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Ärnlöv, Johan (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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(creator_code:org_t)
- Chicago : American Medical Association, 2011
- 2011
- Engelska.
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Ingår i: Journal of the American Medical Association (JAMA). - Chicago : American Medical Association. - 0098-7484 .- 1538-3598. ; 306:10, s. 1113-1121
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: Experimental data suggest that cathepsin S, a cysteine protease, is involved in the complex pathways leading to cardiovascular disease and cancer. However, prospective data concerning a potential association between circulating cathepsin S levels and mortality are lacking. Objective To investigate associations between circulating cathepsin S levels and mortality in 2 independent cohorts of elderly men and women.Design, Setting, and Participants: Prospective study using 2 community-based cohorts, the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1009; mean age: 71 years; baseline period: 1991-1995; median follow-up: 12.6 years; end of follow-up: 2006) and the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 987; 50% women; mean age: 70 years; baseline period: 2001-2004; median follow-up: 7.9 years; end of follow-up: 2010). Serum samples were used to measure cathepsin S.Main Outcome Measure Total mortality.Results: During follow-up, 413 participants died in the ULSAM cohort (incidence rate: 3.59/100 person-years at risk) and 100 participants died in the PIVUS cohort (incidence rate: 1.32/100 person-years at risk). In multivariable Cox regression models adjusted for age, systolic blood pressure, diabetes, smoking status, body mass index, total cholesterol, high-density lipoprotein cholesterol, antihypertensive treatment, lipid-lowering treatment, and history of cardiovascular disease, higher serum cathepsin S was associated with an increased risk for mortality (ULSAM cohort: hazard ratio [HR] for 1-unit increase of cathepsin S, 1.04 [95% CI, 1.01-1.06], P = .009; PIVUS cohort: HR for 1-unit increase of cathepsin S, 1.03 [95% CI, 1.00-1.07], P = .04). In the ULSAM cohort, serum cathepsin S also was associated with cardiovascular mortality (131 deaths; HR for quintile 5 vs quintiles 1-4, 1.62 [95% CI, 1.11-2.37]; P = .01) and cancer mortality (148 deaths; HR for 1-unit increase of cathepsin S, 1.05 [95% CI, 1.01-1.10]; P = .01).Conclusions Among elderly individuals in 2 independent cohorts, higher serum cathepsin S levels were associated with increased mortality risk. Additional research is needed to delineate the role of cathepsin S and whether its measurement might have clinical utility.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- cathepsin S
- mortality
- cardiovascular mortality
- cancer mortality
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jobs, Elisabeth
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Ingelsson, Erik
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Risérus, Ulf
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Nerpin, Elisabet
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Jobs, Magnus
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Sundström, Johan
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visa fler...
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Basu, Samar
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Larsson, Anders
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Lind, Lars
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Ärnlöv, Johan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Hälsovetenskap
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet