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Plasma folate and t...
Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function.
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- Van Guelpen, Bethany (författare)
- Umeå universitet,Patologi,Umeå University
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- Hultdin, Johan (författare)
- Umeå universitet,Klinisk kemi,Umeå University ; Skellefteå Hospital
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- Johansson, Ingegerd (författare)
- Umeå universitet,Kariologi,Umeå University
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- Witthöft, Cornelia (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science
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- Weinehall, Lars (författare)
- Umeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University ; National Public Health Institute
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- Eliasson, Mats (författare)
- Umeå universitet,Medicin,Umeå University ; Sunderby Hospital
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Umeå University
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi,Umeå University
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- Jansson, Jan-Håkan (författare)
- Umeå universitet,Medicin
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- Winkvist, Anna, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk näringslära,Institute of Medicine, Department of Clinical Nutrition,University of Gothenburg
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(creator_code:org_t)
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- Wiley, 2009
- 2009
- Engelska.
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Ingår i: Journal of internal medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 266:2, s. 182-95
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To investigate the relationship between plasma folate, vitamin B12 and total homocysteine concentrations, dietary intake of folate and vitamins B12, B6 and B2, and the risk of first acute myocardial infarction (MI). DESIGN: Nested case-referent study with up to 13 years of follow-up. SETTING: The population-based Northern Sweden Health and Disease Study, with 73 879 participants at the time of case ascertainment. SUBJECTS: A total of 571 MI cases (406 men) and 1569 matched referents. Of the cases, 530 had plasma samples available, and 247 had dietary B-vitamin intake data. RESULTS: Plasma concentrations of folate were inversely associated, and total homocysteine positively associated, with the risk of MI, independently of each other and of a number of established and novel cardiovascular risk factors, including renal function [multivariate odds ratio for highest vs. lowest quintile of folate 0.52 (95% CI 0.31-0.84), P for trend = 0.036, and homocysteine 1.92 (95% CI 1.20-3.09), P for trend = 0.006]. For plasma vitamin B12 concentrations, and vitamin B12, B6 and B2 intake, no clear risk relationship was apparent. Though not statistically significant, the results for folate intake were consistent with those for plasma concentrations. CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function. Although randomized trials of folic acid supplementation are needed to determine causality, our findings highlight the potential importance of folate, or sources of folate, in incident cardiovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adult
- Aged
- Dietary Supplements
- Female
- Folic Acid
- blood
- Follow-Up Studies
- Health Surveys
- Homocysteine
- blood
- Humans
- Male
- Middle Aged
- Myocardial Infarction
- blood
- etiology
- Odds Ratio
- Prospective Studies
- Riboflavin
- blood
- Risk
- Sex Distribution
- Sweden
- Vitamin B 12
- blood
- Vitamin B 6
- blood
- acute myocardial infarction
- Natural Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Van Guelpen, Bet ...
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Hultdin, Johan
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Johansson, Ingeg ...
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Witthöft, Cornel ...
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Weinehall, Lars
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Eliasson, Mats
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Hallmans, Göran
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Palmqvist, Richa ...
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Jansson, Jan-Håk ...
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Winkvist, Anna, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Lantbruksvetensk ...
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och Livsmedelsvetens ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of inter ...
- Av lärosätet
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Göteborgs universitet
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Sveriges Lantbruksuniversitet
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Umeå universitet
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