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Breast cancer incid...
Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study
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- Orgeas, C (författare)
- Dept of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
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- Sanner, Karin (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Hall, Per (författare)
- Karolinska Institutet
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Conner, Peter (författare)
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- Holte, Jan (författare)
- Carl von Linne Kliniken, Uppsala University Hospital, Uppsala, Sweden
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Nilsson, Staffan, 1956 (författare)
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- Sundfeldt, Karin, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
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Persson, Ingemar (författare)
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Chia, Kee Seng (författare)
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- Wedren, Sara (författare)
- Karolinska Institutet
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- Dickman, Paul (författare)
- Karolinska Institutet
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- Czene, Kamilla (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Am J Obstet Gynecol. - : Elsevier BV. - 0002-9378 .- 1097-6868. ; 200:1
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. STUDY DESIGN: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. RESULTS: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). CONCLUSION: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Adult
- Breast Neoplasms/*chemically induced/epidemiology
- Chorionic Gonadotropin/*adverse effects/therapeutic use
- Clomiphene/*adverse effects/therapeutic use
- Cohort Studies
- Female
- Fertility Agents
- Female/*adverse effects/therapeutic use
- Humans
- Incidence
- Infertility
- Female/*drug therapy
- Prospective Studies
- Sweden/epidemiology
- ovulation induction
- postmenopausal women
- fertility drugs
- risk
- therapy
- health
- carcinogenesis
- prevention
- pregnancy
- estrogens
- Incidence
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Orgeas, C
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Sanner, Karin
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Hall, Per
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Conner, Peter
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Holte, Jan
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Nilsson, Staffan ...
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Sundfeldt, Karin ...
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Persson, Ingemar
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Chia, Kee Seng
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Wedren, Sara
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Dickman, Paul
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Czene, Kamilla
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Am J Obstet Gyne ...
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola
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Uppsala universitet
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Karolinska Institutet