Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study

Orgeas, CDept of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden (författare)

OBJECTIVE: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. STUDY DESIGN: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. RESULTS: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). CONCLUSION: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Adult
Breast Neoplasms/*chemically induced/epidemiology
Chorionic Gonadotropin/*adverse effects/therapeutic use
Clomiphene/*adverse effects/therapeutic use
Cohort Studies
Female
Fertility Agents
Female/*adverse effects/therapeutic use
Humans
Incidence
Infertility
Female/*drug therapy
Prospective Studies
Sweden/epidemiology
ovulation induction
postmenopausal women
fertility drugs
risk
therapy
health
carcinogenesis
prevention
pregnancy
estrogens
Incidence
MEDICINE

Sanner, KarinUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)karisann (författare)
Hall, PerKarolinska Institutet (författare)
Conner, Peter (författare)
Holte, JanCarl von Linne Kliniken, Uppsala University Hospital, Uppsala, Sweden (författare)
Nilsson, Staffan,1956 (författare)
Sundfeldt, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg(Swepub:gu)xsukar (författare)
Persson, Ingemar (författare)
Chia, Kee Seng (författare)
Wedren, SaraKarolinska Institutet (författare)
Dickman, PaulKarolinska Institutet (författare)
Czene, KamillaKarolinska Institutet (författare)
Dept of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, SwedenInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

Av författaren/redakt...: Orgeas, C; Sanner, Karin; Hall, Per; Conner, Peter; Holte, Jan; Nilsson, Staffan ...; visa fler...; Sundfeldt, Karin ...; Persson, Ingemar; Chia, Kee Seng; Wedren, Sara; Dickman, Paul; Czene, Kamilla; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

Av lärosätet: Göteborgs universitet; Chalmers tekniska högskola; Uppsala universitet; Karolinska Institutet

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