Herpes simplex virus infection downmodulates NKG2D ligand expression.

Herpes simplex virus (HSV) type 1 infection may cause orofacial infections in humans. The virus resides in a latent form in neural ganglia and occasionally reactivates and infects epithelial cells. Natural killer (NK) cells have been implicated in immune control of herpes virus infections, possibly by downmodulating major histocompatibility complex (MHC) class I and by other, as yet unidentified, mechanisms. Upon HSV-1 infection of cell lines, surface levels of NKG2D ligands MHC class I related proteins (MIC) A and UL16 binding protein 2 were downmodulated due to late viral gene product(s). As also MHC class I levels were reduced by HSV-1, NK cell recognition of HeLa cells was not affected by infection. Total cellular MICA contents remained unchanged, suggesting masking, internalization or intracellular retention of MICA as possible mechanisms of viral downregualtion of MICA surface levels. Furthermore, NK cells from patients with active HSV-1 infection had a tendency towards increased expression level of the activating receptor NKG2D. These data support a role for NKG2D-MICA interactions in immune responses to HSV-1 reactivation.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adolescent
Adult
Cell Line
Tumor
Cells
Cultured
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Gene Expression
drug effects
Hela Cells
Herpes Simplex
blood
immunology
virology
Herpesvirus 1
Human
genetics
immunology
Herpesvirus 2
Human
genetics
immunology
Histocompatibility Antigens Class I
genetics
metabolism
Humans
Immediate-Early Proteins
genetics
Intercellular Signaling Peptides and Proteins
genetics
metabolism
Interleukin-15
pharmacology
Killer Cells
Natural
cytology
metabolism
virology
Ligands
Male
Middle Aged
Mutation
Reverse Transcriptase Polymerase Chain Reaction
Ubiquitin-Protein Ligases
genetics
Young Adult

D'Amato, MKarolinska Institutet (författare)
Studahl, Marie,1957Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xstuma (författare)
Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xberto (författare)
Kärre, KKarolinska Institutet (författare)
Berg, LKarolinska Institutet (författare)
Karolinska InstitutetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

Ingår i:Scandinavian journal of immunology: Wiley69:5, s. 429-361365-30830300-9475

Av författaren/redakt...: Schepis, D; D'Amato, M; Studahl, Marie, ...; Bergström, Tomas ...; Kärre, K; Berg, L

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

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