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Effects of family h...
Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study.
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Hayden, Kathleen M (författare)
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Zandi, Peter P (författare)
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West, Nancy A (författare)
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Tschanz, Joann T (författare)
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Norton, Maria C (författare)
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Corcoran, Chris (författare)
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Breitner, John C S (författare)
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Welsh-Bohmer, Kathleen A (författare)
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- Skoog, Ingmar, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- American Medical Association (AMA), 2009
- 2009
- Engelska.
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Ingår i: Archives of neurology. - : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 66:11, s. 1378-83
- Relaterad länk:
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https://jamanetwork....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline. DESIGN, SETTING, AND PARTICIPANTS: Residents of Cache County, Utah, aged 65 years or older, were invited to participate. At baseline, 2957 participants provided DNA for genotyping of APOE and a detailed FHxAD. They also completed the Modified Mini-Mental State Examination. Cognitive status was reexamined after 3 and 7 years. We used mixed-effects models to examine the association among FHxAD, APOE epsilon4, and cognitive trajectories. MAIN OUTCOME MEASURE: Modified Mini-Mental State Examination score trajectories over time. RESULTS: Compared with participants who did not have APOE epsilon4 or an FHxAD, those with APOE epsilon4 scored lower on the Modified Mini-Mental State Examination at baseline (-0.70 points; 95% confidence interval [CI], -1.15 to -0.24). Participants with an FHxAD and APOE epsilon4 differed less, if at all, in baseline score (-0.46 points; 95% CI, -1.09 to 0.16) but declined faster during the 7-year study (-9.75 points [95% CI, -10.82 to -8.67] vs -2.91 points [95% CI, -3.37 to -2.44]). After exclusion of participants who developed prodromal AD or incident dementia, the group with an FHxAD and APOE epsilon4 declined much less during the 7-year study (-1.54; 95% CI, -2.59 to -0.50). CONCLUSIONS: Much of the association among FHxAD, APOE epsilon4, and cognitive decline may be attributed to undetected incipient (latent) disease. In the absence of latent disease, the 2 factors do not appear individually to be associated with cognitive decline, although they may be additive.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Aged
- Alzheimer Disease
- genetics
- Apolipoprotein E4
- genetics
- Cognition Disorders
- genetics
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Neuropsychological Tests
- Risk Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hayden, Kathleen ...
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Zandi, Peter P
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West, Nancy A
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Tschanz, Joann T
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Norton, Maria C
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Corcoran, Chris
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visa fler...
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Breitner, John C ...
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Welsh-Bohmer, Ka ...
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Skoog, Ingmar, 1 ...
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Göteborgs universitet