Sökning: onr:"swepub:oai:gup.ub.gu.se/109142" > Outcome in a prospe...
Fältnamn | Indikatorer | Metadata |
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000 | 06289naa a2201033 4500 | |
001 | oai:gup.ub.gu.se/109142 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:c8827f47-7e02-4715-9cea-78859ae42e38 | |
009 | oai:DiVA.org:uu-254513 | |
009 | oai:prod.swepub.kib.ki.se:119053523 | |
009 | oai:DiVA.org:liu-20169 | |
024 | 7 | a https://gup.ub.gu.se/publication/1091422 URI |
024 | 7 | a https://doi.org/10.1200/JCO.2008.21.56812 DOI |
024 | 7 | a https://lup.lub.lu.se/record/14126922 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2545132 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1190535232 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201692 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)uud (SwePub)kid (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Baumann, Piau Karolinska Institutet4 aut |
245 | 1 0 | a Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. |
264 | 1 | c 2009 |
520 | a PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty-seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant difference in survival between patients with T1 or T2 tumors. At a median follow-up of 35 months (range, 4 to 47 months), 27 patients (47%) were deceased, seven as a result of lung cancer and 20 as a result of concurrent disease. Kaplan-Meier estimated local control at 3 years was 92%. Local relapse was observed in four patients (7%). Regional relapse was observed in three patients (5%). Nine patients (16%) developed distant metastases. The estimated risk of all failure (local, regional, or distant metastases) was increased in patients with T2 (41%) compared with those with T1 (18%) tumors (P = .027). CONCLUSION: With a 3-year local tumor control rate higher than 90% with limited toxicity, SBRT emerges as state-of-the-art treatment for medically inoperable stage I NSCLC and may even challenge surgery in operable instances. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Aged | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Disease-Free Survival | |
653 | a Dyspnea | |
653 | a etiology | |
653 | a Fatigue | |
653 | a etiology | |
653 | a Female | |
653 | a Fibrosis | |
653 | a etiology | |
653 | a Humans | |
653 | a Lung Neoplasms | |
653 | a pathology | |
653 | a surgery | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Neoplasm Recurrence | |
653 | a Local | |
653 | a Pleural Effusion | |
653 | a etiology | |
653 | a Prospective Studies | |
653 | a Radiosurgery | |
653 | a adverse effects | |
653 | a methods | |
653 | a Small Cell Lung Carcinoma | |
653 | a pathology | |
653 | a surgery | |
653 | a Treatment Outcome | |
653 | a MEDICINE | |
700 | 1 | a Nyman, Jan,d 19564 aut |
700 | 1 | a Hoyer, Morten4 aut |
700 | 1 | a Wennberg, Beritu Karolinska Institutet4 aut |
700 | 1 | a Gagliardi, Giovannau Karolinska Institutet4 aut |
700 | 1 | a Lax, Ingmaru Karolinska Institutet4 aut |
700 | 1 | a Drugge, Ninniu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut |
700 | 1 | a Ekberg, Lars4 aut |
700 | 1 | a Friesland, Signeu Karolinska Institutet4 aut |
700 | 1 | a Johansson, Karl-Axelu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut |
700 | 1 | a Lund, Jo-Asmund4 aut |
700 | 1 | a Morhed, Elisabeth4 aut |
700 | 1 | a Nilsson, Kristina,d 1967-u Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)kristnil |
700 | 1 | a Levin, Nina4 aut |
700 | 1 | a Paludan, Merete4 aut |
700 | 1 | a Sederholm, Christeru Östergötlands Läns Landsting,Linköpings universitet,Lungmedicin,Hälsouniversitetet,Lungmedicinska kliniken US4 aut0 (Swepub:liu)chrse81 |
700 | 1 | a Traberg, Anders4 aut |
700 | 1 | a Wittgren, Lenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)rfa-lwi |
700 | 1 | a Lewensohn, Rolfu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för kliniska vetenskaper4 org |
773 | 0 | t Journal of clinical oncology : official journal of the American Society of Clinical Oncologyg 27:20, s. 3290-6q 27:20<3290-6x 1527-7755x 0732-183X |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/19414667?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1200/JCO.2008.21.5681y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/109142 |
856 | 4 8 | u https://doi.org/10.1200/JCO.2008.21.5681 |
856 | 4 8 | u https://lup.lub.lu.se/record/1412692 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254513 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119053523 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20169 |
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